Simultaneous multiwavelength laminar optical tomography

Spatially resolved reflectance measurements can be used to characterize the depth-resolved optical properties of superficial tissues. However, until now, rapid acquisition of multiwavelength data has been hindered by multiplexing problems. We report on a novel multiwavelength laminar optical tomogra...

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Bibliographic Details
Published inOptics letters Vol. 33; no. 22; p. 2710
Main Authors Burgess, Sean A, Bouchard, Matthew B, Yuan, Baohong, Hillman, Elizabeth M C
Format Journal Article
LanguageEnglish
Published United States 15.11.2008
Subjects
Equipment Design
Equipment Failure Analysis
Image Enhancement - instrumentation
Microscopy, Fluorescence, Multiphoton - instrumentation
Reproducibility of Results
Sensitivity and Specificity
Tomography, Optical - instrumentation
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Summary:Spatially resolved reflectance measurements can be used to characterize the depth-resolved optical properties of superficial tissues. However, until now, rapid acquisition of multiwavelength data has been hindered by multiplexing problems. We report on a novel multiwavelength laminar optical tomography system capable of acquiring data from multiple source-detector separations at three wavelengths simultaneously. Such data can allow in vivo depth-resolved spectroscopic imaging of absorbers, such as oxy- and deoxyhemoglobin, or of multiple fluorophores, that is unaffected by motion artifacts at frame rates exceeding 100 Hz. The system design and phantom validation studies are presented.
ISSN:0146-9592
DOI:10.1364/OL.33.002710