Rheumatoid arthritis associated with osteopetrosis

• Published in: Modern rheumatology Vol. 19; no. 6; pp. 687 - 690
• Main Authors: Kadono, Yuho, Tanaka, Sakae, Nishino, Jinju, Nishimura, Keita, Nakamura, Ichiro, Miyazaki, Tsuyoshi, Takayanagi, Hiroshi, Nakamura, Kozo
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.12.2009; Informa Healthcare
• Subjects: Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - diagnostic imaging; Arthritis, Rheumatoid - genetics; Bone and Bones - pathology; Bone Density - genetics; Bone diseases; Bone Resorption - complications; Bone Resorption - diagnostic imaging; Bone Resorption - genetics; Case Report; Case studies; Disease Progression; Genetic disorders; Humans; Inflammation - pathology; Male; Medicine; Medicine & Public Health; Middle Aged; Orthopedics; Osteopetrosis - complications; Osteopetrosis - diagnostic imaging; Osteopetrosis - genetics; Radiography; Rheumatoid arthritis; Rheumatology; Bone erosion; Osteoclast; Osteopetrosis; Rheumatoid arthritis
• ISSN: 1439-7595; 1439-7609
• DOI: 10.1007/s10165-009-0208-7

Osteopetrosis is an inherited disorder characterized by reduced bone resorption. We here report a rare case of osteopetrosis associated with rheumatoid arthritis. The patient was diagnosed as autosomal dominant osteopetrosis type II in his youth and developed rheumatoid arthritis at 42 years of age. In spite of the severe inflammation and rapid progression of cartilage destruction, the progression of bone erosion was slow in this patient.