Haemopoietic cell transplantation in patients living with HIV

Haemopoietic cell transplantation is established as a standard treatment approach for people living with HIV who have haematological malignancies with poor prognosis. Studies with autologous and allogeneic haemopoietic cell transplantation suggest that HIV status does not adversely affect outcomes,...

Full description

Saved in:
Bibliographic Details
Published inThe lancet HIV Vol. 7; no. 9; p. e652
Main Authors Ambinder, Richard F, Capoferri, Adam A, Durand, Christine M
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.2020
Subjects
Antiretroviral Therapy, Highly Active
Disease Management
Disease Susceptibility
Genetic Predisposition to Disease
Graft vs Host Disease - etiology
Hematologic Neoplasms - complications
Hematologic Neoplasms - therapy
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic Stem Cell Transplantation - methods
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
Homozygote
Humans
Mutation
Receptors, CCR5
Transplantation, Autologous
Transplantation, Homologous
Treatment Outcome
Online AccessGet more information

Cover

More Information
Summary:Haemopoietic cell transplantation is established as a standard treatment approach for people living with HIV who have haematological malignancies with poor prognosis. Studies with autologous and allogeneic haemopoietic cell transplantation suggest that HIV status does not adversely affect outcomes, provided that there is adequate infection prophylaxis. Attention to possible drug-drug interactions is important. Allogeneic haemopoietic cell transplantation substantially reduces the long-term HIV reservoir when complete donor chimerism is established. When transplants from CCR5Δ32 homozygous donors are used, HIV cure is possible.
ISSN:2352-3018
DOI:10.1016/S2352-3018(20)30117-X