Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance

• Published in: Cancer biology & therapy Vol. 25; no. 1; p. 2306676
• Main Authors: Ye, Chun, Liu, Xiao, Liu, Zilun, Pan, Chuxuan, Zhang, Xiaowei, Zhao, Zhanyi, Sun, Haitao
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 31.12.2024
• Subjects: Carcinogenesis; Cell Transformation, Neoplastic; Colorectal Neoplasms; Fusobacterium nucleatum; Humans; Review; Stomach Neoplasms; tumor resistance; tumor metastasis; tumorigenesis; Fusobacterium nucleatum; mechanism
• ISSN: 1538-4047; 1555-8576
• DOI: 10.1080/15384047.2024.2306676

, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in cancer progression and prognosis. While extensive research has revealed mechanistic links between and colorectal cancer, a comprehensive review spanning its presence and metastatic implications in cancers beyond colorectal origin is conspicuously absent. This paper broadens our perspective from colorectal cancer to various malignancies associated with , including oral, pancreatic, esophageal, breast, and gastric cancers. Our central focus is to unravel the mechanisms governing colonization, initiation, and promotion of metastasis across diverse cancer types. Additionally, we explore 's adverse impacts on cancer therapies, particularly within the domains of immunotherapy and chemotherapy. Furthermore, this paper underscores the clinical research significance of as a potential tumor biomarker and therapeutic target, offering a novel outlook on its applicability in cancer detection and prognostic assessment.