Stimuli-responsive nanogel composites and their application in nanomedicine
Nanogels are nanosized crosslinked polymer networks capable of absorbing large quantities of water. Specifically, smart nanogels are interesting because of their ability to respond to biomedically relevant changes like pH, temperature, etc. In the last few decades, hybrid nanogels or composites have...
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| Published in | Chemical Society reviews Vol. 44; no. 17; pp. 6161 - 6186 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
07.10.2015
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Nanogels are nanosized crosslinked polymer networks capable of absorbing large quantities of water. Specifically, smart nanogels are interesting because of their ability to respond to biomedically relevant changes like pH, temperature,
etc.
In the last few decades, hybrid nanogels or composites have been developed to overcome the ever increasing demand for new materials in this field. In this context, a hybrid refers to nanogels combined with different polymers and/or with nanoparticles such as plasmonic, magnetic, and carbonaceous nanoparticles, among others. Research activities are focused nowadays on using multifunctional hybrid nanogels in nanomedicine, not only as drug carriers but also as imaging and theranostic agents. In this review, we will describe nanogels, particularly in the form of composites or hybrids applied in nanomedicine.
We highlight the description of stimuli responsive nanogels in the form of composites and their application in nanomedicine. |
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| Bibliography: | Enrico Miceli received the BSc in Chemistry from the University of Padova (Italy) in 2007. In 2013 he received the MSc in Chemistry from the Freie Universität Berlin (Germany). In 2014 he started his PhD studies in the research group of Prof. Marcelo Calderón in collaboration with Prof. Joachim Dzubiella. He is involved in the investigation of the interaction between proteins and thermoresponsive nanogels. Dr Julian Bergueiro received his BS and MS in Chemistry from the University of Santiago de Compostela (Spain) in 2007 and 2008, respectively. In 2013 he received his PhD from USC under the supervision of Prof. S. Lopez. In 2012 he joined the group of Prof. R. Riguera to work on the synthesis and characterization of stimuli-response helical polymers and poly(phenylacetylene)s@gold nano-particle nanocomposites. He joined Prof. M. Calderón group in 2013 to carry out his postdoctoral research at Freie Universität Berlin. Recently he was awarded with a Dahlem International Net-work Postdocs Fellowship to develop gold based thermoresponsive nanogels as nanocarriers. Mazdak Asadian-Birjand received his master degree in chemistry at the Freie Universitaet Berlin (Germany) in 2011. In the same year he started his PhD studies under the supervision of Prof. M. Calderón and Prof. R. Haag. His research is focused on the synthesis and biochemical evaluation of environmentally responsive nanogels for biomedical applications. Dr Maria Molina received her BS (Hons) in Chemistry from the National University of Rio Cuarto (Argentina) in 2007. In 2007 she obtained a CONICET Fellowship to undertake her PhD studies (2011) in the group of Prof. Cesar Barbero (National University of Rio Cuarto) working on the preparation of smart hydrogels as drug delivery systems. In 2012 she started her postdoctoral research at Freie Universität Berlin, under the supervision of Prof. M. Calderón and Prof. R. Haag. Her current research is focused on the preparation of responsive nanogels for anticancer therapy. In 2013 she was awarded an Alexander von Humboldt postdoctoral fellowship from the Georg Forster Program. Dr Juan Balach received his PhD degree in Chemistry from National University of Rio Cuarto in 2011 supervised by Prof. César Barbero and was a postdoctoral fellow (2012) in the Department of Colloid Chemistry at the Max Planck Institute of Colloids and Interfaces, Germany. Since 2013, he has been a Research Associate at the Institute for Complex Materials, Leibniz Institute for Solid State and Materials Research (IFW) Dresden, Germany. His research interests mainly focus on the rational design of advanced carbon-based materials for electrochemical energy storage applications. Marcelo Calderón is an Assistant Professor for Macromolecular and Organic Chemistry at the Department of Biology, Chemistry, and Pharmacy from the Freie Universität Berlin, Germany. Dr Calderón received his PhD in organic chemistry in 2007 from the National University of Córdoba, Argentina, under the supervision of Prof. Miriam Strumia. In 2007 he joined the Research Group of Prof. Rainer Haag at the Freie Universitat Berlin for his Postdoctoral work, where he pursued the development of polymer-drug conjugates for the passive targeted delivery of drugs, genes, and imaging probes. Dr Calderón was the recipient of the Arthur K. Doolittle Award in 2010 (ACS, Polymer Materials), the Cesar Milstein Fellowship in 2011 (Ministry of Science, Technology and Productive Innovation, Argentina), and the NanoMatFutur Grant for Young Scientists from the German Ministry of Science in 2012 (BMBF). ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/c5cs00199d |