Ampullosporin A, a peptaibol from Sepedonium ampullosporum HKI-0053 with neuroleptic-like activity

• Published in: Behavioural brain research Vol. 203; no. 2; pp. 232 - 239
• Main Authors: Berek, I., Becker, A., Schröder, H., Härtl, A., Höllt, V., Grecksch, G.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 05.11.2009; Elsevier
• Subjects: Adult and adolescent clinical studies; Ampullosporin; Animals; Antipsychotic Agents - adverse effects; Antipsychotic Agents - pharmacology; Anxiety - chemically induced; Apomorphine - pharmacology; Avoidance Learning - drug effects; Behavioral psychophysiology; Biological and medical sciences; Body Temperature - drug effects; Brain - metabolism; Catalepsy - chemically induced; Conditioned avoidance; Dizocilpine Maleate - pharmacology; Dopamine; Dopamine - metabolism; Elevated plus-maze; Fundamental and applied biological sciences. Psychology; Glutamate; Glutamic Acid - metabolism; Hyperkinesis - chemically induced; Hyperkinesis - metabolism; Locomotor activity; Male; Medical sciences; Motor Activity - drug effects; Neuropharmacology; Peptides - adverse effects; Peptides - pharmacology; Pharmacology. Drug treatments; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Psychopharmacology; Psychoses; Rat; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1 - metabolism; Receptors, Dopamine D2 - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; Rotarod Performance Test; Schizophrenia; Sepedonium ampullosporum; Social Behavior; Social interactions; apo; Dopamine; Rat; amp; Schizophrenia; EPS; Glutamate; TD; hal; Social interactions; APD; Ampullosporin; ket; Elevated plus-maze; Conditioned avoidance; Locomotor activity; sal; Neuroleptic; Psychotropic; Rodentia; Catecholamine; Psychosis; Locomotion; Vertebrata; Mammalia; Social interaction; Animal; Excitatory aminoacid; Neurotransmitter; Avoidance
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2009.05.012

The potential neuroleptic-like effect of ampullosporin A, a new peptaibol, isolated from the fungus Sepedonium ampullosporum HKI-0053, was characterized using specific behavioural models and methods. Ampullosporin A (amp) disrupted the retrieval of a well-trained conditioned reaction and normalized the behavioural effects of subchronic ketamine treatment in the social interaction test in a dose which showed only inconsiderable side effects. The experiments demonstrated that the substance did not antagonize the apomorphine (apo) induced hyperactivity. On the other hand, the locomotor stimulation induced by the NMDA receptor antagonist MK-801 was nearly completely suppressed by ampullosporin A, supposing interactions with the glutamatergic system. Binding studies demonstrated no interaction with dopaminergic D 1 and D 2 receptors. However, amp can alter the activity of glutamate receptors. The results resemble characteristics of an atypical neuroleptic drug. But further experiments are necessary to validate the suggested neuroleptic-like activity.