Concurrent exercise does not prevent recognition memory deficits induced by beta-amyloid in rats

• Published in: Physiology & behavior Vol. 243; p. 113631
• Main Authors: Lima, Karine Ramires, Schmidt, Helen Lidiane, Daré, Leticia Rossi, Soares, Caroline Bitencourt, Lopes, Luiza Freitas, Carpes, Felipe P, Mello-Carpes, Pâmela Billig
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2022
• Subjects: Alzheimer Disease - complications; Alzheimer Disease - prevention & control; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid beta-Peptides - toxicity; Animals; Disease Models, Animal; Hippocampus - metabolism; Humans; Memory Disorders - etiology; Memory Disorders - prevention & control; Neurodegeneration; Rats; Rats, Wistar; Running; Strength; Training; Training; Running; Neurodegeneration; Alzheimer's disease; Strength
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/j.physbeh.2021.113631

•Concurrent exercise does not prevent recognition memory deficits in Aβ rats.•Concurrent exercise increases hippocampal reactive oxygen species in Aβ rats.•Running exercise prevents recognition memory deficits in Aβ rats.•Running and strength exercises decrease oxidative stress in Aβ rats. Alzheimer's disease affects thousands of people worldwide. Alternatives aiming to prevent the disease or reduce its symptoms include different physical exercise configurations. Here we investigate the potential of concurrent exercise to prevent recognition memory deficits in an Alzheimer's disease-like model induced by the hippocampal beta-amyloid (Aβ) injection in Wistar rats. We demonstrate that the concurrent exercise, which included running and strength exercises performed in the same exercise session, is ineffective in preventing recognition memory deficits in the Aβ rats. Besides, higher levels of reactive oxygen species were found in the concurrent exercise group's hippocampus. The running exercise administrated alone prevented recognition memory impairments.