Exposure to pesticides and heterozygote genotype of GSTP1-Alw26I are associated to Parkinson's disease

• Published in: Arquivos de neuro-psiquiatria Vol. 71; no. 7; pp. 446 - 452
• Main Authors: Longo, Gabriela S, Pinhel, Marcela S, Sado, Caroline L, Gregório, Michele L, Amorim, Gisele S, Florim, Greiciane S, Mazeti, Camila M, Martins, Denise P, Oliveira, Fábio N, Tognola, Waldir A, Nakazone, Marcelo A, Souza, Dorotéia R S
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Academia Brasileira de Neurologia - ABNEURO 01.07.2013; Academia Brasileira de Neurologia (ABNEURO)
• Subjects: Aged; Aged, 80 and over; Alcoholism; Case-Control Studies; DNA-Cytosine Methylases - genetics; doença de Parkinson; Female; Gene Frequency; Glutathione S-Transferase pi - genetics; glutationa transferase; Heterozygote; Humans; Male; Middle Aged; NEUROSCIENCES; Parkinson Disease, Secondary - chemically induced; Parkinson Disease, Secondary - genetics; Pesticides - toxicity; polimorfismo genético; Polymerase Chain Reaction; Polymorphism, Genetic - genetics; PSYCHIATRY; Risk Factors; Sex Factors; Site-Specific DNA-Methyltransferase (Adenine-Specific) - genetics; xenobióticos; glutathione transferase; doença de Parkinson; xenobiotics; Parkinson disease; glutationa transferase; genetic polymorphism; xenobióticos; polimorfismo genético
• ISSN: 0004-282X; 1678-4227; 1678-4227; 0004-282X
• DOI: 10.1590/0004-282X20130060

This study aimed to analyze the frequency of GSTP1-Alw26I polymorphism and to estimate its association with toxic substances in Parkinson's disease (PD). A study group with 154 patients - subdivided into familial and sporadic PD groups - and 158 elderly individuals without the disease (control group) were evaluated. GSTP1-Alw26I polymorphism was analyzed by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP). Patients were significantly more exposed to pesticides compared with the control group (p=0.0004), and the heterozygote genotype associated to exposure to pesticides also prevailed in patients (p=0.0001). Wild homozygote genotype was related to tobacco use (p=0.043) and alcoholism (p=0.033) in familial PD patients. Exposure to pesticides is associated to PD, whose effect can be enhanced when combined with the heterozygote genotype of GSTP1-Alw26I. Also, large genetic and environmental studies considering tobacco use, alcoholism, GSTP1 and PD are necessary to confirm our findings.