Evaluation of antipyretic potential of Clitoria ternatea L. extract in rats

• Published in: Phytomedicine (Stuttgart) Vol. 11; no. 4; pp. 323 - 326
• Main Authors: Parimaladevi, B., Boominathan, R., Mandal, Subhash C.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 2004; Urban & Fischer Verlag; Elsevier Science Ltd
• Subjects: Administration, Oral; Analgesics, Non-Narcotic - administration & dosage; Analgesics, Non-Narcotic - pharmacology; Analgesics, Non-Narcotic - therapeutic use; Animals; Anti-pyretic; Antipyretics; Beans; Body Temperature - drug effects; Clitoria; Dose-Response Relationship, Drug; Female; Fever - prevention & control; Gastrointestinal agents; Health aspects; Legumes; Male; Mimosaceae; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Roots; Rats; Rats, Wistar; Root of Clitoria ternatea (MECTR); Yeasts; India; Anti-pyretic; Root of Clitoria ternatea (MECTR)
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1078/0944711041495191

The methanol extract of Clitoria ternatea L. root (MECTR) blue flowered variety (Family: Fabaceae), was evaluated for its anti-pyretic potential on normal body temperature and yeast-induced pyrexia in albino rats. Yeast suspension (10 ml/kg body wt.) increased rectal temperature after 19 hours of subcutaneous injection. The extract, at doses of 200, 300 and 400 mg/kg body wt., p.o., produced significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner. The effect extended up to 5 hours after the drug administration. The anti-pyretic effect of the extract was comparable to that of paracetamol (150 mg/kg body wt., p.o.), a standard anti-pyretic agent.