Electrocardiogram changes and therapeutic desipramine and 2-hydroxy-desipramine concentrations in elderly depressives
ECG parameters in elderly depressed in-patients were assessed during routine desipramine treatment. Significant changes (prolonged PR and PRS intervals and a decreased QTc interval) were found, related only to steady state concentrations of desipramine's major metabolite--2-hydroxy-desipramine....
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Published in | British journal of psychiatry Vol. 148; p. 676 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
01.06.1986
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Subjects | |
Online Access | Get more information |
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Summary: | ECG parameters in elderly depressed in-patients were assessed during routine desipramine treatment. Significant changes (prolonged PR and PRS intervals and a decreased QTc interval) were found, related only to steady state concentrations of desipramine's major metabolite--2-hydroxy-desipramine. Potentially clinically significant changes developed in 40% of the patients. All serum drug concentrations were within therapeutic limits. Previous assurances about desipramines's cardiac safety in the elderly may need to be re-evaluated. |
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ISSN: | 0007-1250 |
DOI: | 10.1192/bjp.148.6.676 |