Long-term inhaling ultrafine zinc particles increases cardiac wall stresses elevated by myocardial infarction

• Published in: Biomedical engineering online Vol. 23; no. 1; pp. 1 - 10
• Main Authors: Wang, Songyu, Wang, Haifang, Li, Li, Niu, Pei, Yin, Zhongjie, Huo, Yunlong
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 05.08.2024; BioMed Central; BMC
• Subjects: Air pollution; Analysis; Cardiovascular disease; Cardiovascular diseases; Care and treatment; Complications and side effects; Control engineering; Coronary artery disease; Echocardiography; Environmental aspects; Fibroblasts; Health aspects; Heart attack; Heart attacks; Heart diseases; Heart failure; Hemodynamic monitoring; Hemodynamics; Inhalation; Mechanics; Mechanics (physics); Methods; Myocardial infarction; Outdoor air quality; Particles; Respiration; Stresses; Ultrafines; Zinc; United Kingdom
• ISSN: 1475-925X; 1475-925X
• DOI: 10.1186/s12938-024-01275-3

The analysis of cardiac wall mechanics is of importance for understanding coronary heart diseases (CHD). The inhalation of ultrafine particles could deteriorate CHD. The aim of the study is to investigate the effects of cardiac wall mechanics on rats of myocardial infarction (MI) after long-term inhalation of ultrafine Zn particles. Cardiac wall stresses and strains were computed, based on echocardiographic and hemodynamic measurements. It was found that MI resulted in the significantly elevated stresses and the reduced strains. The short-term inhalation of ultrafine Zn particles decreased stresses and increased strains in MI rats, but the long-term inhalation had the opposite effects. Hence, the short-term inhalation of ultrafine Zn particles could alleviate the MI-induced LV dysfunction while the long-term inhalation impaired it.