Synthesis and Characterization of Metabolites and Potential Impurities of Lansoprazole, an Antiulcerative Drug

Lansoprazole (Prevacid) is an antiulcerative drug used for the treatment of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger-Ellison syndrome. During the bulk synthesis of lansoprazole, we have observed five impurities: lansoprazole N-oxide, lansoprazole sulfone N-oxide, lansoprazole...

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Bibliographic Details
Published inSynthetic communications Vol. 38; no. 20; pp. 3477 - 3489
Main Authors Reddy, Ganta Madhusudhan, Mukkanti, K., Kumar, T. Laxmi, Babu, J. Moses, Reddy, Padi Pratap
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 29.09.2008
Taylor & Francis
Subjects
Chemistry
Chemistry, Organic
HR-MS
impurities
lansoprazole
Physical Sciences
Science & Technology
spectral characterization
synthesis
spectral characterization
synthesis
PERFORMANCE LIQUID-CHROMATOGRAPHY
ACID-RELATED DISORDERS
PANTOPRAZOLE
lansoprazole
THERAPEUTIC EFFICACY
PLASMA
HR-MS
impurities
OMEPRAZOLE
PHARMACOKINETIC PROPERTIES
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Summary:Lansoprazole (Prevacid) is an antiulcerative drug used for the treatment of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger-Ellison syndrome. During the bulk synthesis of lansoprazole, we have observed five impurities: lansoprazole N-oxide, lansoprazole sulfone N-oxide, lansoprazole sulfide, lansoprazole sulfone and N-aralkyl lansoprazole. The present work describes the synthesis and characterization of these impurities.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910802162934