Relationship between vitamin D and adolescents' hypothyroidism - a cross-sectional study
To detect the relationship between 25(OH)D and hypothyroidism in adolescents. A total of 180 adolescents were included in the current study, which was conducted in West Kazakhstan (Aktobe) over 2 years. After thorough evaluation, blood samples were collected from the studied participants to measure...
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Published in | Przegla̜d menopauzalny Vol. 22; no. 4; pp. 186 - 190 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Poland
Termedia Publishing House
01.01.2023
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Subjects | |
Online Access | Get full text |
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Summary: | To detect the relationship between 25(OH)D and hypothyroidism in adolescents.
A total of 180 adolescents were included in the current study, which was conducted in West Kazakhstan (Aktobe) over 2 years. After thorough evaluation, blood samples were collected from the studied participants to measure the thyroid stimulating hormone (TSH), free thyroxine (T4), prolactin, glycosylated haemoglobin, and 25(OH)D. Participants were classified into a 25(OH)D-deficient group (study group) and controls. MedCalc and correlation analysis (Pearson's correlation) were used to detect the odds of hypothyroidism and the relationship between 25(OH)D and adolescents' hypothyroidism, respectively.
Thyroid-stimulating hormone was statistically higher in the 25(OH)D-deficient group than in the normal controls (3.71 ±1.4 mIU/ml vs. 2.67 ±0.99) (
= 0.0006), and the free T4 was statistically lower in the 25(OH)D-deficient group than in normal controls (1.4 ±0.56 ng/ml vs. 1.5 ±0.4) (
= 0.0008). The 25(OH)D deficient group had higher odds of subclinical (OR 4.89;
= 0.016), and clinical hypothyroidism (OR 4.3;
= 0.013) compared to controls. A significant negative correlation between the 25(OH)D and TSH (
= -0.793;
< 0.00001), and a significant positive correlation between the 25(OH)D and free T4 (
0.55;
< 0.00001) were detected in this study.
The thyroid-stimulating hormone was statistically higher and the free T4 was statistically lower in the 25(OH)D-deficient group than in normal controls. The 25(OH)D-deficient group had higher odds of both subclinical and clinical hypothyroidism compared to controls. A significant negative correlation between the 25(OH)D and TSH, and a significant positive correlation between the 25(OH)D and the free T4 were detected in this study. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1643-8876 2299-0038 |
DOI: | 10.5114/pm.2023.133280 |