Effect of increased excursion of the ankle on the severity of acute eccentric contraction-induced strain injury in the gastrocnemius: an in vivo rat study

Although muscle strain injury models are frequently employed, highly invasive procedures, including surgical intervention, are typically used to produce these models. In this study, a minimally invasive model of acute strain injury was produced with a single eccentric contraction. The authors tested...

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Bibliographic Details
Published inThe American journal of sports medicine Vol. 32; no. 5; p. 1263
Main Authors Song, Hongsun, Nakazato, Koichi, Nakajima, Hiroyuki
Format Journal Article
LanguageEnglish
Published United States 01.07.2004
Subjects
Animals
Ankle Joint - physiopathology
Electric Stimulation
Male
Models, Biological
Muscle Contraction - physiology
Muscle, Skeletal - injuries
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Random Allocation
Range of Motion, Articular - physiology
Rats
Rats, Wistar
Sprains and Strains - physiopathology
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Summary:Although muscle strain injury models are frequently employed, highly invasive procedures, including surgical intervention, are typically used to produce these models. In this study, a minimally invasive model of acute strain injury was produced with a single eccentric contraction. The authors tested whether the severity of strain injury in the in vivo gastrocnemius depends on the excursion of the ankle. Controlled laboratory study. Animals were randomly assigned to 2 groups: a small range of motion group (90-105 degrees, n = 10) and a large range of motion group (90-125 degrees, n = 10). Tetanically activated gastrocnemius muscles with percutaneous electrical stimulation were simultaneously elongated by forced dorsiflexion of the ankle joint. Isometric tetanic force of the large range of motion group was significantly lower than the pretreatment control 1, 2, and 3 days after treatment. Such reduction was not observed in the small range of motion group. Apparent pathologic damage was observed in the large range of motion group throughout the study period of 10 days. A larger range of motion causes more damage in eccentric contraction by using the in vivo model. This in vivo model is useful to elucidate mechanisms of prevention and recovery of strain injury.
ISSN:0363-5465
DOI:10.1177/0363546503262199