Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives

Nucleic acid-based aptamers have emerged as efficient delivery carriers of therapeutics. Thanks to their unique features, they can be, to date, considered one of the best targeting moieties, allowing the specific recognition of diseased cells and avoiding unwanted off-target effects on healthy tissu...

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Published inGenes Vol. 9; no. 11; p. 529
Main Authors Esposito, Carla Lucia, Catuogno, Silvia, Condorelli, Gerolama, Ungaro, Paola, de Franciscis, Vittorio
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 31.10.2018
MDPI
Subjects
Angiogenesis
Apoptosis
Aptamers
Breast cancer
Cancer therapies
Chemotherapy
Chimeras
DNA methylation
Drug resistance
Genes
Growth factors
HIV
Human immunodeficiency virus
Kinases
Ligands
Medical research
MicroRNAs
Peptides
Polyethylene glycol
Review
chimeras
aptamer
targeted delivery
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Summary:Nucleic acid-based aptamers have emerged as efficient delivery carriers of therapeutics. Thanks to their unique features, they can be, to date, considered one of the best targeting moieties, allowing the specific recognition of diseased cells and avoiding unwanted off-target effects on healthy tissues. In this review, we revise the most recent contributes on bispecific and multifunctional aptamer therapeutic chimeras. We will discuss key examples of aptamer-mediated delivery of nucleic acid and peptide-based therapeutics underlying their great potentiality and versatility. Achieved objectives and challenges will be highlighted as well.
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All authors contributed equally to this work.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes9110529