Sodium appetite in adult rats following ω-3 polyunsaturated fatty acid deficiency in early development

• Published in: Appetite Vol. 55; no. 3; pp. 393 - 397
• Main Authors: Weisinger, R.S., Armitage, J.A., Chen, N., Begg, D.P., Mathai, M.L., Jayasooriya, A.P., Sinclair, A.J., Weisinger, H.S.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.12.2010; Elsevier
• Subjects: adult animals; Angiotensin-Converting Enzyme Inhibitors - pharmacology; animal models; Animals; Appetite; Biological and medical sciences; blood chemistry; Captopril - pharmacology; deficiency diseases; Deficiency Diseases - complications; early development; enzyme inhibition; experimental diets; Fatty Acids, Omega-3 - administration & dosage; Feeding. Feeding behavior; Female; Fluid intake; Fos; Fundamental and applied biological sciences. Psychology; Furosemide; homeostasis; lipid metabolism; Medical sciences; Metabolic diseases; nutrient balance; omega-3 fatty acids; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Sprague-Dawley; Salt appetite; Sodium - deficiency; Sodium balance; sodium chloride; Sodium Chloride, Dietary - administration & dosage; Vertebrates: anatomy and physiology, studies on body, several organs or systems; ω-3 fatty acid deficiency; ω-3 fatty acid deficiency; Sodium balance; Fos; Fluid intake; Salt appetite; Appetite; Feeding behavior; Nutrition; Rat; Deficiency; Psychology; Rodentia; Lipids; n-3 fatty acid; Oligofructose; Salt; Vertebrata; Mammalia; Sodium; Adult animal; Development; Unsaturated fatty acid; Early; Psychopathology
• ISSN: 0195-6663; 1095-8304
• DOI: 10.1016/j.appet.2010.07.006

We examined the effect of ω-3 polyunsaturated fatty acid (PUFA) deficiency during development on sodium appetite. Being raised on an ω-3 PUFA deficient diet increased the intake of 0.5 M NaCl following furosemide-induced sodium depletion by 40%. This occurred regardless of the diet they were maintained on later in life, and the increased consumption persisted for 3 days. In a second study, animals were administered furosemide and low-dose captopril. Sodium consumption of deficient raised animals was again higher than that of the control raised. Fos immunoreactivity in brain areas associated with sodium appetite and excretion were not influenced by diet. Our findings indicate that inadequate dietary ω-3 PUFA during development results in an exaggerated sodium appetite later in life.