Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

• Published in: International journal of molecular sciences Vol. 20; no. 24; p. 6284
• Main Authors: Seo, Dae Yun, Ko, Jeong Rim, Jang, Jung Eun, Kim, Tae Nyun, Youm, Jae Boum, Kwak, Hyo-Bum, Bae, Jun Hyun, Kim, Amy Hyein, Ko, Kyung Soo, Rhee, Byoung Doo, Han, Jin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.12.2019; MDPI
• Subjects: Animals; Apoptosis; Biomarkers; Blood pressure; Calcium (mitochondrial); Cardiomyocytes; Cardiomyopathy; Cardiovascular disease; Clinical Studies as Topic; Congestive heart failure; Coronary vessels; Diabetes; Diabetes mellitus; Diabetic Cardiomyopathies - genetics; Diabetic Cardiomyopathies - metabolism; Diabetic Cardiomyopathies - physiopathology; Diabetic Cardiomyopathies - therapy; Energy; Exercise; Exercise Therapy - methods; Fatty acids; Fibrosis; Glucose; Heart failure; Humans; Hyperglycemia; Hypertension; Insulin resistance; Kinases; Metabolism; Microvasculature; Mitochondria; Mortality; Myocardium - metabolism; Oxidation; Oxidative Stress; Physical fitness; Physiology; Proteins; Quality of life; Review; Risk factors; Signal transduction; Signs and symptoms; Therapeutic targets; heart failure; exercise; cardiomyopathy; diabetes
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20246284

Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising due to diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function and calcium regulation. This review summarizes the recent scientific findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.