Plant-derived peptides improving lipid and glucose metabolism

• Published in: Peptides (New York, N.Y. : 1980) Vol. 142; p. 170577
• Main Authors: Nagaoka, Satoshi, Takeuchi, Asahi, Banno, Arata
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2021
• Subjects: Atherosclerosis; Cholesterol; Diabetes; Glucose - metabolism; Lifestyle disease; Lipid; Lipid Metabolism - drug effects; Obesity; Peptide; Peptide Fragments - pharmacology; Plant; Plant Proteins - chemistry; Plant Proteins - metabolism; Soybean protein; Triglyceride; Obesity; Plant; Lifestyle disease; Atherosclerosis; Diabetes; Triglyceride; Peptide; Soybean protein; Cholesterol; Lipid
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/j.peptides.2021.170577

•Some plant-derived peptides ameliorate the collapses of metabolic homeostasis.•Soy possesses proteins and peptides with the improvement of the metabolic disorder.•Plant-derived bioactive peptides target the wide variety of biomolecules.•There are a few in vivo active plant-derived peptides with physiological effects.•Further in vivo studies will lead us to apply to the management of diseases. Plant protein-derived peptides, focusing especially on soybean protein-derived peptides have considerable effects on metabolic regulation and modulation such as cholesterol lowering, triglyceride lowering, anti-obesity, inhibition of fatty acid synthase, and antidiabetic effects. The molecules targeted to study the metabolic regulatory functions of the peptides included the following: intestinal cholesterol micelle, cholesterol metabolism-related genes for cholesterol lowering, triglyceride metabolism-related genes for triglyceride lowering and anti-obesity, dipeptidyl peptidase-IV (DPP-IV), α-amylase, α-glucosidase, or glucose metabolism-related genes for lowering blood glucose levels. This review article outlines the physiological functions of plant protein-derived peptides for the improvement of lipid and glucose metabolism in vitro or in vivo.