Mathematical models of cell cycle regulation

• Published in: Briefings in bioinformatics Vol. 6; no. 2; pp. 163 - 177
• Main Authors: FUB, Hendrik, DUBITZKY, Werner, DOWNES, C. Stephen, KURTH, Mary Jo
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.06.2005; Oxford Publishing Limited (England)
• Subjects: Algorithms; Animals; Biological and medical sciences; Biology; Cancer; Cell cycle; Cell Cycle - physiology; Cell Cycle Proteins - metabolism; Computer Simulation; Feedback - physiology; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - physiology; General aspects; Genes; Humans; Mathematical models; Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects); Models, Biological; Ordinary differential equations; Parameter estimation; Processes; Proteins; Signal Transduction - physiology; Studies; Biotechnology; Cell cycle; Network; Cell biology; Cell division; Molecular complex; Review; Mathematical model; Bioinformatics; Protein
• ISSN: 1467-5463; 1477-4054
• DOI: 10.1093/bib/6.2.163

The cell division cycle is a fundamental process of cell biology and a detailed understanding of its function, regulation and other underlying mechanisms is critical to many applications in biotechnology and medicine. Since a comprehensive analysis of the molecular mechanisms involved is too complex to be performed intuitively, mathematical and computational modelling techniques are essential. This paper is a review and analysis of recent approaches attempting to model cell cycle regulation by means of protein-protein interaction networks.