Low-dose radiation attenuates chemical mutagenesis in vivo

The biological effects of low-dose radiation are not only of social concern but also of scientific interest. The radioadaptive response, which is defined as an increased radioresistance by prior exposure to low-dose radiation, has been extensively studied both in vitro and in vivo. Here we briefly r...

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Bibliographic Details
Published inJournal of radiation research Vol. 50; no. 5; pp. 401 - 405
Main Authors Kakinuma, Shizuko, Yamauchi, Kazumi, Amasaki, Yoshiko, Nishimura, Mayumi, Shimada, Yoshiya
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.09.2009
Subjects
Animals
Chromosome Aberrations - radiation effects
Humans
Models, Biological
Mutagenesis - physiology
Mutagenesis - radiation effects
Neoplasms, Radiation-Induced - physiopathology
Radiation Dosage
Radiation Tolerance - physiology
Radiation Tolerance - radiation effects
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Summary:The biological effects of low-dose radiation are not only of social concern but also of scientific interest. The radioadaptive response, which is defined as an increased radioresistance by prior exposure to low-dose radiation, has been extensively studied both in vitro and in vivo. Here we briefly review the radioadaptive response with respect to mutagenesis, survival rate, and carcinogenesis in vivo, and introduce our recent findings of cross adaptation in mouse thymic cells, that is, the suppressive effect of repeated low-dose radiation on mutation induction by the alkylating agent N-ethyl-N-nitrosourea.
ISSN:0449-3060
1349-9157
DOI:10.1269/jrr.09051