Excess dietary iodine differentially affects thyroid gene expression in diabetes, thyroiditis-prone versus -resistant BioBreeding (BB) rats

• Published in: Molecular nutrition & food research Vol. 55; no. 12; pp. 1875 - 1886
• Main Authors: Swist, Eleonora, Chen, QiXuan, Qiao, Cunye, Caldwell, Don, Gruber, Heidi, Scoggan, Kylie A.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.12.2011; WILEY‐VCH Verlag; Wiley
• Subjects: Animals; Autoimmune thyroiditis; BB rats; Biological and medical sciences; Carrier Proteins - drug effects; Carrier Proteins - genetics; Carrier Proteins - metabolism; Diabetes Mellitus - metabolism; Diabetes Mellitus - pathology; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Diet; Fatty Acid-Binding Proteins - drug effects; Fatty Acid-Binding Proteins - genetics; Fatty Acid-Binding Proteins - metabolism; Female; Food industries; Fundamental and applied biological sciences. Psychology; Gene expression; Insulitis; Iodine; Iodine - administration & dosage; Iodine - adverse effects; Nutrition Disorders - pathology; Perilipin-1; Phosphoproteins - drug effects; Phosphoproteins - genetics; Phosphoproteins - metabolism; Rats; Rats, Inbred BB; RNA, Messenger - drug effects; RNA, Messenger - genetics; RNA, Messenger - metabolism; Thyroid Gland - metabolism; Thyroid Gland - pathology; Thyroid Hormones - blood; Thyroiditis, Autoimmune - chemically induced; Thyroiditis, Autoimmune - genetics; Thyroiditis, Autoimmune - metabolism; Thyroiditis, Autoimmune - pathology; Up-Regulation; Insulitis; Vertebrata; Mammalia; Rat; Rodentia; lodine; Gene expression; Autoimmune thyroiditis; BB rats; Iodine
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.201100299

Scope: To identify genes involved in the susceptibility to iodine‐induced autoimmune thyroiditis. Methods and results: Diabetes, thyroiditis‐prone (BBdp) and ‐resistant (BBc) rats were fed either a control or a high‐iodine diet for 9 wk. Excess iodine intake increased the incidence of insulitis and thyroiditis in BBdp rats. BBdp rats fed the high‐iodine diet that did not develop thyroiditis had higher mRNA levels of Fabp4, Cidec, perilipin, Pparγ and Slc36a2 than BBdp rats fed the control diet and BBc rats fed either the control or the high‐iodine diet. BBdp rats fed the high‐iodine diet that did develop thyroiditis had higher mRNA levels of Cidec, Icam1, Ifitm1, and Slpi than BBdp rats fed the control diet and BBc rats fed either the control or the high‐iodine diet. BBdp rats that did develop thyroiditis had lower mRNA levels of Fabp4, perilipin and Slc36a2 but higher mRNA levels of Icam1, Ifitm1 and Slpi than BBdp that did not develop thyroiditis. Excess dietary iodine also increased the protein levels of Fabp4, Cidec and perilipin in BBdp rats. Conclusion: Differential expression of thyroid genes in BBdp versus BBc rats caused by excess dietary iodine may be implicated in autoimmune thyroiditis and insulitis pathogenesis.