Immunization with recombinant baculovirus expressing the VP6 protein of grass carp reovirus induces immunity in grass carp

• Published in: Virologica Sinica Vol. 29; no. 4; pp. 261 - 263
• Main Authors: Li, Qin, Liu, Liyue, Lin, Li, Li, Zeming, Liu, Guangxin, Wu, Shusheng, Wang, Min, Li, Lijuan, Yuan, Junfa, Yuan, Gailing, Liu, Xueqin
• Format: Journal Article
• Language: English
• Published: Heidelberg Wuhan Institute of Virology, CAS 01.08.2014; KeAi Publishing Communications Ltd
• Subjects: Animals; Antibodies, Viral - immunology; Baculoviridae - genetics; Baculoviridae - metabolism; Biochemistry; Biomedical and Life Sciences; Biomedicine; Carps - immunology; Carps - virology; Ctenopharyngodon idella; Fish Diseases - immunology; Fish Diseases - prevention & control; Fish Diseases - virology; Gene Expression; iDEN; Immunity; Immunization; Letter; Medical Microbiology; Microbial Genetics and Genomics; Microbiology; Oncology; Reoviridae - genetics; Reoviridae - immunology; Reoviridae Infections - immunology; Reoviridae Infections - veterinary; Reoviridae Infections - virology; Viral Proteins - administration & dosage; Viral Proteins - genetics; Viral Proteins - immunology; Viral Vaccines - administration & dosage; Viral Vaccines - genetics; Viral Vaccines - immunology; Virology; VP6 protein; 接种; 杆状病毒表达; 疫苗研制; 草鱼呼肠孤病毒; 蛋白; 诱导免疫; 重组; Grass Carp; Recombinant Baculovirus; Recombinant Baculoviruses; Phosphate Buffer Solution; VIROLOGICA SINICA
• ISSN: 1674-0769; 1995-820X
• DOI: 10.1007/s12250-014-3460-8

Grass carp reovirus（GCRV）,a member of the genus Aquareovirus in the family Reoviridae（Attoui H,et al,2002）,is one of the most virulent aquareoviruses iden-tified so far,leading to high fatality rates（up to 85%）of fingerlings and yearlings of grass carp（Fang Q,et al,2007）.No commercial vaccines against GCRV infection have been developed as yet.