Metastasis: To and fro

• Published in: Journal of oral and maxillofacial pathology : JOMFP Vol. 21; no. 3; pp. 463 - 464
• Main Authors: Baldawa, Prachi, Shirol, Pallavi, Alur, Jyoti, Kulkarni, Venkatesh V
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.09.2017; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: Angiogenesis; Cancer; Cancer metastasis; Carcinogenesis; Cell adhesion & migration; Cell cycle; Cell proliferation; Enzymes; Extracellular matrix; Fibroblasts; Gene expression; Lymphatic system; Metastases; Metastasis; Molecular modelling; Motility; Oral cancer; Pathology; Proteins; Review; Rodents; Signal transduction; Therapeutics; Tumor suppressor genes; Tumors; Vascular endothelial growth factor; metastatic process; primary tumor; Cancer
• ISSN: 0973-029X; 1998-393X
• DOI: 10.4103/jomfp.JOMFP_158_17

Cancer is one of the most life threatening diseases afflicting mankind. Oral carcinogenesis is a multifactorial process involving numerous genetic events that alter normal functions of oncogenes and tumour suppressor genes. These changes lead to a cell phenotype with increased cell proliferation, with loss of cell cohesion, and infiltration of adjacent tissue thus causing distant metastasis. The fact that cancer patients might develop metastasis after years or even decades from diagnosis of the primary tumor makes the metastatic process even more complex and the disease more deadly. The promise of this article is to enhance the understanding on molecular mechanisms underlying metastasis and provide a better approach towards development of novel therapeutic treatment modalities.