Intensive Combination LDL-Lowering Therapy in a Patient With Homozygous Familial Hypercholesterolemia

We present a young boy with a diagnosis of homozygous familial hypercholesterolemia who presented with statin and ezetimibe resistance. The patient received lipoprotein apheresis at 6 years of age. His low-density lipoprotein cholesterol levels significantly were reduced by adding lomitapide and evi...

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Bibliographic Details
Published inJACC. Case reports Vol. 29; no. 12; p. 102367
Main Authors Tada, Hayato, Okada, Hirofumi, Kawashiri, Masa-aki, Takamura, Masayuki
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 19.06.2024
Elsevier
Subjects
Case Report
genetic disorders
hypercholesterolemia
lipid metabolism disorders
FH
LDLRAPI
LDL
genetic disorders
MTTP
ANGPTL3
PCSK9
HoFH
LDLR
hypercholesterolemia
lipid metabolism disorders
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Summary:We present a young boy with a diagnosis of homozygous familial hypercholesterolemia who presented with statin and ezetimibe resistance. The patient received lipoprotein apheresis at 6 years of age. His low-density lipoprotein cholesterol levels significantly were reduced by adding lomitapide and evinacumab, and his carotid plaque started to regress. [Display omitted]
ISSN:2666-0849
2666-0849
DOI:10.1016/j.jaccas.2024.102367