Waking‐hour cerebral activations in nightmare disorder: A resting‐state functional magnetic resonance imaging study

• Published in: Psychiatry and clinical neurosciences Vol. 70; no. 12; pp. 573 - 581
• Main Authors: Shen, Chanchan, Wang, Jiawei, Ma, Guorong, Zhu, Qisha, He, Hongjian, Ding, Qiuping, Fan, Hongying, Lu, Yanxia, Wang, Wei
• Format: Journal Article
• Language: English
• Published: Melbourne John Wiley & Sons Australia, Ltd 01.12.2016; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adult; anterior cingulate cortex; Brain Mapping - methods; Cerebral Cortex - physiopathology; Dreams - physiology; emotion; Female; Humans; hypervigilance; Magnetic Resonance Imaging; Male; nightmare; NMR; Nuclear magnetic resonance; parietal lobule; Sleep Wake Disorders - physiopathology; Young Adult; emotion; parietal lobule; nightmare; anterior cingulate cortex; hypervigilance
• ISSN: 1323-1316; 1440-1819; 1440-1819
• DOI: 10.1111/pcn.12455

Aim The purpose of the current study was to explore the cerebral areas involved in nightmare disorder. Methods Fifteen nightmare disorder patients and 15 healthy volunteers were invited to undergo resting‐state functional magnetic resonance imaging and to complete the Nightmare Experience Questionnaire. Results The nightmare disorder patients scored higher on the Physical Effect and Horrible Stimulation scales, had higher values of regional homogeneity in clusters within the left anterior cingulate cortex and right inferior parietal lobule, and lower regional homogeneity values within the left superior and inferior frontal gyri and bilateral middle occipital gyri. Physical Effect was negatively correlated with regional homogeneity values in anterior cingulate cortex and inferior parietal lobule in the nightmare disorder group, and was positively correlated with regional homogeneity value in the inferior frontal gyrus in the healthy control group. Conclusion To our best knowledge, this is the first neuroimaging study on nightmare disorder, and we have characterized the cerebral activities underlying altered hyperarousal and emotion regulation in nightmare disorder at resting‐state.