Regenerative Wound Surgery: Practical Application of Regenerative Medicine in the OR

• Published in: AORN journal Vol. 109; no. 3; pp. 298 - 317
• Main Authors: Gillette, Brian, PhD, Criscitelli, Theresa, EdD, RN, CNOR, Howell, Raelina, MD, Woods, Jon, MD, Acerra, Michael, BA, Gorenstein, Scott, MD
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2019
• Subjects: Bone marrow; cell therapy; chronic wounds; Cytokines; Drug resistance; Granulocytes; Growth factors; Humans; Leg ulcers; Medical/Surgical; Medicine; Mortality; Nurses; Nursing; Operating Rooms - methods; Operating Rooms - trends; Pain management; Regenerative medicine; Regenerative Medicine - methods; Regenerative Medicine - trends; Stem cells; Surgeons; Surgery; Surgical Procedures, Operative - methods; Surgical Procedures, Operative - trends; Transplants & implants; venous leg ulcers; Wound healing; Wound Healing - physiology; wound surgery; United States > US; venous leg ulcers; wound surgery; regenerative medicine; cell therapy; chronic wounds
• ISSN: 1878-0369; 0001-2092; 1878-0369
• DOI: 10.1002/aorn.12615

Abstract Chronic nonhealing wounds cause significant morbidity and mortality and remain a challenging condition to treat. Regenerative wound surgery involves operative debridement of wounds to remove dead and healing‐impaired tissue and bacterial contamination and, subsequently, the application of regenerative medicine treatments to accelerate healing. Regenerative treatments aim to restore native tissue structure and function by targeting biological mechanisms underlying impaired healing. A wide range of regenerative modalities are used for treating chronic and complex wounds, including decellularized scaffolds, living engineered donor tissues, autologous stem cells, and recombinant growth factors. Each of these modalities has specific and sometimes complex requirements for implementation. The advanced wound care team, including OR staff members, should be aware of how these products are used and regulated. This article highlights some of the common and emerging regenerative treatments that are applied in wound surgery and focuses on how the products are used practically in the OR.