Gold-Conjugated Protein Nanoarrays through Block-Copolymer Lithography: From Fabrication to Biosensor Design

A hole lot of protein: A method to immobilize proteins at defined positions at the single‐molecule level has been developed by using templates structured by block‐copolymer lithography to generate ultrahigh‐density protein nanoarrays (see image). Carbohydrate–lectin (RCA or WGA) interactions on the...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 2; no. 8-9; pp. 1010 - 1015
Main Authors Jung, Jin-Mi, Kwon, Ki Young, Ha, Tai-Hwan, Chung, Bong Hyun, Jung, Hee-Tae
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.08.2006
WILEY‐VCH Verlag
Subjects
Biosensing Techniques - instrumentation
biosensors
block copolymers
Gold
lithography
nanoparticles
Nanotechnology - instrumentation
Protein Array Analysis - instrumentation
proteins
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Summary:A hole lot of protein: A method to immobilize proteins at defined positions at the single‐molecule level has been developed by using templates structured by block‐copolymer lithography to generate ultrahigh‐density protein nanoarrays (see image). Carbohydrate–lectin (RCA or WGA) interactions on the nanoarray surface have remarkably high selectivity and reproducibility and indicate that this approach is applicable for biosensors.
Bibliography:ArticleID:SMLL200600005
This work was supported by grants from the KRIBB Initiative Research Program, CUPS-ERC (KOSEF, Korea), the Protein Chip Technology Program (MOST, Korea), and MOHW (0405-MN01-0604-0007).
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ark:/67375/WNG-601WPTB2-B
This work was supported by grants from the KRIBB Initiative Research Program, CUPS‐ERC (KOSEF, Korea), the Protein Chip Technology Program (MOST, Korea), and MOHW (0405‐MN01‐0604‐0007).
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ISSN:1613-6810
1613-6829
DOI:10.1002/smll.200600005