The interaction of graves' IgG with the thyrotrophin receptor

Sera from patients with Graves' disease contain antibodies which inhibit the binding of thyrotrophin (TSH) to thyroid membranes. Investigations demonstrate that Graves' IgG has similar inhibiting effects on labelled TSH binding to membrane bound receptors, crude detergent solubilised recep...

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Bibliographic Details
Published inFEBS letters Vol. 127; no. 1; pp. 17 - 21
Main Authors Rickards, Carole, Buckland, Paul, Rees Smith, Bernard, Hall, Reginald
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 05.05.1981
Subjects
Animals
Cattle
Chromatography, Affinity
Graves Disease - immunology
Humans
immunoglobulin G
Immunoglobulin G - metabolism
man
Polyethylene Glycols - pharmacology
Receptors, Cell Surface - drug effects
Receptors, Cell Surface - metabolism
Receptors, Thyrotropin
Solubility
Swine
thyrotoxicosis
thyrotropin
Thyrotropin - metabolism
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Summary:Sera from patients with Graves' disease contain antibodies which inhibit the binding of thyrotrophin (TSH) to thyroid membranes. Investigations demonstrate that Graves' IgG has similar inhibiting effects on labelled TSH binding to membrane bound receptors, crude detergent solubilised receptors and detergent solubilised receptors purified by Sepharose-TSH affinity chromatography. Furthermore, the effects of antibody are independent of detergent concentration and no evidence could be obtained for the formation of significant amounts of a complex consisting of antibody, solubilised receptors and TSH. These observations suggest that Graves' IgG contain antibodies which interact directly with the TSH receptor.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(81)80330-4