Association between triglyceride glucose index and carotid intima‐media thickness in obese and nonobese adults

• Published in: Journal of diabetes Vol. 14; no. 9; pp. 596 - 605
• Main Authors: Jia, Xiaojing, Zhu, Yuanyue, Qi, Yan, Zheng, Ruizhi, Lin, Lin, Hu, Chunyan, Zhang, Yi, Wu, Xueyan, Qi, Hongyan, Wei, Ran, Zhang, Jie, Xu, Min, Xu, Yu, Wang, Tiange, Zhao, Zhiyun, Chen, Yuhong, Bi, Yufang, Wang, Weiqing, Li, Mian, Lu, Jieli
• Format: Journal Article
• Language: English
• Published: Melbourne Wiley Publishing Asia Pty Ltd 01.09.2022; John Wiley & Sons, Inc
• Subjects: Adult; Biomarkers; Blood Glucose; Cardiovascular disease; Carotid arteries; Carotid Intima-Media Thickness; Electrolytes; Glucose; Humans; nonlinear relationship; Obesity; Obesity - complications; Prospective Studies; Risk Factors; triglyceride glucose index; Triglycerides; 甘油三酯血糖指数; 非线性关系; 颈动脉内中膜厚度; China; 甘油三酯血糖指数; 肥胖; 颈动脉内中膜厚度; 非线性关系; triglyceride glucose index; nonlinear relationship; carotid intima-media thickness; obesity
• ISSN: 1753-0393; 1753-0407
• DOI: 10.1111/1753-0407.13312

Background The triglyceride glucose (TyG) index is closely associated with subclinical atherosclerosis. However, the association remains inconclusive among obese and nonobese individuals. Methods This prospective study was conducted in 5751 adults with normal carotid intima‐media thickness (CIMT) at baseline. We divided the population into four groups based on the TyG index, which was calculated by the following formula: Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Information on CIMT was acquired by ultrasonography. Incident elevated CIMT was defined as IMT values greater than 0.9 mm at follow‐up. Odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between TyG index and elevated CIMT were estimated using multivariable logistic regression models. Results After a median follow‐up of 4.3 years, 722 (12.6%) individuals had progressed to elevated CIMT. Compared with the second quartile of the TyG index, the first and fourth quartile both conferred higher risks of elevated CIMT after adjusting for potential confounders. In the total population, the ORs for the first and fourth quartile were 1.29 (95% CI, 1.00‐1.66) and 1.42 (95% CI, 1.11‐1.83), respectively. Restricted cubic splines demonstrated an approximately U‐shaped association between TyG index and elevated CIMT among the total and nonobese adults (P for nonlinearity <.05), but not in those with general or abdominal obesity. Conclusions A U‐shaped association was observed between TyG index and elevated CIMT only among nonobese Chinese adults. 摘要 背景 甘油三酯血糖(TyG)指数与亚临床动脉粥样硬化密切相关。然而，肥胖者和非肥胖者之间的联系仍然没有定论。 方法 这项前瞻性研究在5751名基线颈动脉内膜中层厚度(CIMT)正常的成年人中进行。根据TyG指数将人群分为四组，计算公式为:Ln(空腹甘油三酯[mg/dL]×空腹血糖[mg/dL]/2)。超声检查获得CIMT的相关信息。升高的CIMT定义为随访时IMT值大于0.9 mm。用多变量Logistic回归模型估计TyG指数与CIMT升高之间关联的优势比(OR)和95%置信区间(CI)。 结果 经过平均4.3年 的随访，有722例(12.6%)患者进展为CIMT升高。与TyG指数的第二个四分位数相比，在校正了潜在的混杂因素后，第一和第四个四分位数都具有更高的CIMT升高风险。在总人口中，第一和第四个四分位数的OR值分别为1.29(95%CI，1.00~1.66)和1.42(95%CI，1.11~1.83)。限制立方样条法显示TyG指数与非肥胖者和非肥胖者的CIMT升高呈近似的U型相关(P<0.05)，但在一般肥胖者或腹型肥胖者中不存在。 结论 仅在非肥胖的中国成年人中，TyG指数与CIMT升高呈U型相关。 Highlights Many studies have reported that the triglyceride glucose (TyG) index is an inexpensive biochemical marker to assess metabolic and cardiovascular diseases. Our findings indicate that the TyG index is nonlinearly associated with the risk of new‐onset elevated carotid intima‐media thickness (CIMT) during a follow‐up of 4.3 years. We further evaluated such relationship in participants by body size phenotypes. A U‐shaped association between TyG index and elevated CIMT only existed among those without general or abdominal obesity.