Emerging Role of Plasma Microbial Cell-free DNA in the Diagnosis of Pediatric Mucormycosis

Mucormycosis is a rare and devastating angioinvasive infection that can be challenging to diagnose due to the low sensitivity of current noninvasive diagnostics and the lack of a "gold standard" reference test. We describe a retrospective case series of children with suspected mucormycosis...

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Bibliographic Details
Published inThe Pediatric infectious disease journal Vol. 43; no. 7; p. 704
Main Authors Gracia, Michael, Hadley, Emma, Ramchandar, Nanda, Coufal, Nicole G
Format Journal Article
LanguageEnglish
Published United States 01.07.2024
Subjects
Adolescent
Cell-Free Nucleic Acids - blood
Child
Child, Preschool
DNA, Fungal - blood
Female
Humans
Immunocompromised Host
Infant
Male
Mucormycosis - blood
Mucormycosis - diagnosis
Retrospective Studies
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Summary:Mucormycosis is a rare and devastating angioinvasive infection that can be challenging to diagnose due to the low sensitivity of current noninvasive diagnostics and the lack of a "gold standard" reference test. We describe a retrospective case series of children with suspected mucormycosis where plasma microbial cell-free DNA testing was utilized in the diagnostic evaluation to illustrate the ways in which microbial cell-free DNA testing can noninvasively contribute to the evaluation and management of at-risk, immunosuppressed patients suspected of mucormycosis.
ISSN:1532-0987
DOI:10.1097/INF.0000000000004331