Negative symptoms, depression and Alzheimer's disease
Objectives To apply the negative symptoms (NS) concept used in schizophrenia to patients with AD, to compare the results with the frontal lobe perfusion in ethyl cysteinate dimmer (ECD) single‐photon emission computed tomography (SPECT) and with the apolipoprotein E genotype. Method 32 patients with...
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Published in | International journal of geriatric psychiatry Vol. 17; no. 4; pp. 383 - 387 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.04.2002
Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Objectives
To apply the negative symptoms (NS) concept used in schizophrenia to patients with AD, to compare the results with the frontal lobe perfusion in ethyl cysteinate dimmer (ECD) single‐photon emission computed tomography (SPECT) and with the apolipoprotein E genotype.
Method
32 patients with a diagnosis of probable AD were assessed by the Positive and Negative Symptoms Scale (PANSS‐N), the Montgomery and Asberg Depression Scale (MADRS), the NeuroPsychiatric Inventory (NPI), and the Mini‐Mental Status Examination (MMSE). Each patient underwent ECD SPECT and APO E genotyping. PANSS‐N, MADRS, NPI, and MMSE were administered to 19 normal elderly control subjects.
Results
The mean PANSS‐N score for AD patients (20.56, SD: 8, range: 7–40) was significantly higher (p < 0.001) than that of controls (7, SD: 0). MADRS scores were not significantly different (p = 0.75) between AD patients (9.03, SD: 6.14, range: 0–25) and controls (6.2, SD: 3.61, range: 1–15). The NPI apathy score (0–12) was correlated with PANSS‐N (p < 0.001). Correlation between prominent frontal hypoperfusion (six cases) and NS was at the limit of significance. No relation was found between epsilon E4 and NS.
Conclusion
This consideration is important in distinguishing between depression and AD. Copyright © 2002 John Wiley & Sons, Ltd. |
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Bibliography: | ark:/67375/WNG-LJTTJJKV-6 ArticleID:GPS620 istex:2B5E33FACE8AF585E2B97205919AD8CD6FF779F0 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0885-6230 1099-1166 |
DOI: | 10.1002/gps.620 |