Synthesis, Anion-Binding Properties, and In Vitro Anticancer Activity of Prodigiosin Analogues

Pro and anti: Recognition of chloride ion and through‐membrane H+/Cl− ion transport (“symport”) could account for the biological effects (anticancer activity) of prodigiosin, as inferred from model studies involving pyrrole‐based anion receptors designed to mimic the key features of this naturally o...

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Published inAngewandte Chemie (International ed.) Vol. 44; no. 37; pp. 5989 - 5992
Main Authors Sessler, Jonathan L., Eller, Leah R., Cho, Won-Seob, Nicolaou, Sergios, Aguilar, Apolonio, Lee, Jeong Tae, Lynch, Vincent M., Magda, Darren J.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 19.09.2005
WILEY‐VCH Verlag
Wiley
Subjects
Anions - metabolism
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Chemistry
Chemistry, Multidisciplinary
Crystallography, X-Ray
Humans
ion transport
membranes
molecular recognition
nitrogen heterocycles
Physical Sciences
prodigiosin
Prodigiosin - chemistry
Prodigiosin - metabolism
Prodigiosin - pharmacology
Science & Technology
APOPTOSIS
DNA CLEAVAGE
VESICLES
ion transport
prodigiosin
membranes
DYE
ROSEOPHILIN
nitrogen heterocycles
A-RING
molecular recognition
DERIVATIVES
LIPOSOMES
ALKALOIDS
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Summary:Pro and anti: Recognition of chloride ion and through‐membrane H+/Cl− ion transport (“symport”) could account for the biological effects (anticancer activity) of prodigiosin, as inferred from model studies involving pyrrole‐based anion receptors designed to mimic the key features of this naturally occurring pigment (see picture).
Bibliography:ark:/67375/WNG-5F2DG70R-H
ArticleID:ANIE200501740
This work was supported by the National Institutes of Health (GM 58907). Dr. Wyeth Callaway is thanked for providing samples of pyrrole 10. We thank Ms. Beth McNally of Prof. Bradley Smith's group for her help in developing a working liposomal model membrane system.
istex:4ABBB7AB872EE80F9F8EC18D631DAED0A5186EB7
This work was supported by the National Institutes of Health (GM 58907). Dr. Wyeth Callaway is thanked for providing samples of pyrrole
We thank Ms. Beth McNally of Prof. Bradley Smith's group for her help in developing a working liposomal model membrane system.
10
Medline
NIH RePORTER
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200501740