Synthesis, Anion-Binding Properties, and In Vitro Anticancer Activity of Prodigiosin Analogues
Pro and anti: Recognition of chloride ion and through‐membrane H+/Cl− ion transport (“symport”) could account for the biological effects (anticancer activity) of prodigiosin, as inferred from model studies involving pyrrole‐based anion receptors designed to mimic the key features of this naturally o...
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Published in | Angewandte Chemie (International ed.) Vol. 44; no. 37; pp. 5989 - 5992 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
19.09.2005
WILEY‐VCH Verlag Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Pro and anti: Recognition of chloride ion and through‐membrane H+/Cl− ion transport (“symport”) could account for the biological effects (anticancer activity) of prodigiosin, as inferred from model studies involving pyrrole‐based anion receptors designed to mimic the key features of this naturally occurring pigment (see picture). |
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Bibliography: | ark:/67375/WNG-5F2DG70R-H ArticleID:ANIE200501740 This work was supported by the National Institutes of Health (GM 58907). Dr. Wyeth Callaway is thanked for providing samples of pyrrole 10. We thank Ms. Beth McNally of Prof. Bradley Smith's group for her help in developing a working liposomal model membrane system. istex:4ABBB7AB872EE80F9F8EC18D631DAED0A5186EB7 This work was supported by the National Institutes of Health (GM 58907). Dr. Wyeth Callaway is thanked for providing samples of pyrrole We thank Ms. Beth McNally of Prof. Bradley Smith's group for her help in developing a working liposomal model membrane system. 10 Medline NIH RePORTER ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.200501740 |