Pilot trial of albuterol in Duchenne and Becker muscular dystrophy
The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; and 2) manual muscle testing (MMT). Isometric knee extensor strength and MMT scores wer...
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Published in | Neurology Vol. 62; no. 6; p. 1006 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
23.03.2004
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Subjects | |
Online Access | Get more information |
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Summary: | The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; and 2) manual muscle testing (MMT). Isometric knee extensor strength and MMT scores were significantly higher in patients taking albuterol vs placebo. Therefore, 12-week treatment with extended-release albuterol may increase strength in patients with dystrophinopathies. A larger, double-blind, randomized study is necessary to confirm these results. |
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ISSN: | 1526-632X |
DOI: | 10.1212/01.wnl.0000118530.71646.0f |