Pilot trial of albuterol in Duchenne and Becker muscular dystrophy

The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; and 2) manual muscle testing (MMT). Isometric knee extensor strength and MMT scores wer...

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Bibliographic Details
Published inNeurology Vol. 62; no. 6; p. 1006
Main Authors Fowler, E G, Graves, M C, Wetzel, G T, Spencer, M J
Format Journal Article
LanguageEnglish
Published United States 23.03.2004
Subjects
Adrenergic beta-Agonists - therapeutic use
Albuterol - therapeutic use
Child
Cross-Over Studies
Double-Blind Method
Dystrophin - genetics
Follow-Up Studies
Humans
Isometric Contraction - drug effects
Male
Muscle Contraction - drug effects
Muscular Dystrophy, Duchenne - drug therapy
Muscular Dystrophy, Duchenne - genetics
Mutation
Pilot Projects
Treatment Outcome
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Summary:The authors conducted a randomized, crossover, double-blind, placebo-controlled pilot study of albuterol in nine boys with dystrophinopathies. Primary outcomes were 1) isometric knee extensor and flexor strength; and 2) manual muscle testing (MMT). Isometric knee extensor strength and MMT scores were significantly higher in patients taking albuterol vs placebo. Therefore, 12-week treatment with extended-release albuterol may increase strength in patients with dystrophinopathies. A larger, double-blind, randomized study is necessary to confirm these results.
ISSN:1526-632X
DOI:10.1212/01.wnl.0000118530.71646.0f