HPLC of morphine with electrochemical detection: analysis in human plasma

A method is described for the measurement of morphine in human plasma by ion-paired reverse-phase liquid chromatography. It includes a novel solid-phase extraction of morphine from plasma which is simple, rapid and complete. No known morphine metabolites could be shown to interfere with the measurem...

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Bibliographic Details
Published inAnnals of clinical biochemistry Vol. 21 ( Pt 2); p. 125
Main Authors Moore, R A, Baldwin, D, McQuay, H J, Bullingham, R E
Format Journal Article
LanguageEnglish
Published England 01.03.1984
Subjects
Cardiac Surgical Procedures
Chromatography, High Pressure Liquid
Electrochemistry
Humans
Kinetics
Morphine - blood
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Summary:A method is described for the measurement of morphine in human plasma by ion-paired reverse-phase liquid chromatography. It includes a novel solid-phase extraction of morphine from plasma which is simple, rapid and complete. No known morphine metabolites could be shown to interfere with the measurements. Determination of morphine pharmacokinetics in patients undergoing heart surgery with 1 mg/kg intervenous morphine produced plasma morphine clearances which agreed with established estimates.
ISSN:0004-5632
DOI:10.1177/000456328402100209