Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could ef...

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Published inChemical communications (Cambridge, England) Vol. 50; no. 99; pp. 15792 - 15795
Main Authors Tian, Yanli, Zhang, Xueli, Li, Yuyan, Shoup, Timothy M, Teng, Xin, Elmaleh, David R, Moore, Anna, Ran, Chongzhao
Format Journal Article
LanguageEnglish
Published England 25.12.2014
Subjects
Agglomeration
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - metabolism
Aniline Compounds - chemistry
Aniline Compounds - metabolism
Animals
Attenuation
Conjugates
Crown ethers
Crown Ethers - chemistry
Crown Ethers - metabolism
Hippocampus - metabolism
Hippocampus - pathology
Imaging
Labels
Ligands
Mice
Microscopy, Confocal
Peptide Fragments - chemistry
Peptide Fragments - metabolism
Thiazoles - chemistry
Thiazoles - metabolism
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Summary:In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors contributed equally to this work.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc06029f