Melatonin attenuates polychlorinated biphenyls induced apoptosis in the neuronal cells of cerebral cortex and cerebellum of adult male rats— In vivo

Highlights • PCBs show memory deficits and sensory, motor disorders. • PCBs exposure leads to neuronal death. • PCBs induces neuronal apoptosis via ROS. • Melatonin scavenges ROS protects from neuronal apoptosis. • Antiapoptotic action of melatonin may reside in its antioxidant property.

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Bibliographic Details
Published inEnvironmental toxicology and pharmacology Vol. 36; no. 1; pp. 152 - 163
Main Authors Bavithra, S, Selvakumar, K, Krishnamoorthy, G, Venkataraman, P, Arunakaran, J
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2013
Subjects
Animals
Apoptosis
Apoptosis - drug effects
Caspase 8 - genetics
Caspase 8 - metabolism
Cells, Cultured
Cerebellum - cytology
Cerebral Cortex - cytology
Emergency
Environmental Pollutants - toxicity
Fas Ligand Protein - genetics
Fas Ligand Protein - metabolism
Glial Fibrillary Acidic Protein - genetics
Glial Fibrillary Acidic Protein - metabolism
Male
Melatonin
Melatonin - pharmacology
Neurodegeneration
Neurofilament Proteins - genetics
Neurofilament Proteins - metabolism
Neuronal cells
Neurons - drug effects
Neurons - metabolism
Neurons - pathology
Neuroprotective Agents - pharmacology
NF-kappa B - genetics
PCBs
Polychlorinated Biphenyls - toxicity
Proto-Oncogene Proteins c-bcl-2 - genetics
Rats
Rats, Wistar
PCBs
Melatonin
Neuronal cells
Neurodegeneration
Apoptosis
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Summary:Highlights • PCBs show memory deficits and sensory, motor disorders. • PCBs exposure leads to neuronal death. • PCBs induces neuronal apoptosis via ROS. • Melatonin scavenges ROS protects from neuronal apoptosis. • Antiapoptotic action of melatonin may reside in its antioxidant property.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2013.03.005