The microRNA-449 family inhibits TGF-β-mediated liver cancer cell migration by targeting SOX4
Graphical abstract
Saved in:
| Published in | Journal of hepatology Vol. 66; no. 5; pp. 1012 - 1021 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.05.2017
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Graphical abstract |
|---|---|
| AbstractList | Graphical abstract BACKGROUND & AIMSModulation of microRNA expression is a potential treatment for hepatocellular carcinoma (HCC). Therefore, the epigenetically regulated microRNA-449 family (miR-449a, miR-449b, miR-449c) was characterized with regards to its functional effects and target genes in HCC.METHODSAfter transfection of miR-449a, miR-449b, and/or miR-449c, tumor-relevant functional effects were analyzed using in vitro assays and a xenograft mouse model. Binding specificities, target genes, and regulated pathways of each miRNA were identified by microarray analyses. Target genes were validated by luciferase reporter assays and expression analyses in vitro. Furthermore, target gene expression was analyzed in 61 primary human HCCs compared to normal liver tissue.RESULTSTumor suppressive effects, binding specificities, target genes, and regulated pathways of miR-449a and miR-449b differed from those of miR-449c. Transfection of miR-449a, miR-449b, and/or miR-449c inhibited cell proliferation and migration, induced apoptosis, and reduced tumor growth to different extents. Importantly, miR-449a, miR-449b, and, to a lesser degree, miR-449c directly targeted SOX4, which codes for a transcription factor involved in epithelial-mesenchymal transition and HCC metastasis, and thereby inhibited TGF-β-mediated cell migration.CONCLUSIONSThis study provides detailed insights into the regulatory network of the epigenetically regulated miRNA-449 family and, for the first time, describes distinct tumor suppressive effects and target specificities of miR-449a, miR-449b, and miR-449c. Our results indicate that particularly miR-449a and miR-449b may be considered for miRNA replacement therapy to prevent HCC progression and metastasis.LAY SUMMARYIn this study, we demonstrated that the microRNA-449 family acts as a tumor suppressor in liver cancer by causing cell death and inhibiting cell migration. These effects are caused by downregulation of the oncogene SOX4, which is frequently overexpressed in liver cancer. We conclude that the microRNA-449 family may be a target for liver cancer therapy. Modulation of microRNA expression is a potential treatment for hepatocellular carcinoma (HCC). Therefore, the epigenetically regulated microRNA-449 family (miR-449a, miR-449b, miR-449c) was characterized with regards to its functional effects and target genes in HCC. After transfection of miR-449a, miR-449b, and/or miR-449c, tumor-relevant functional effects were analyzed using in vitro assays and a xenograft mouse model. Binding specificities, target genes, and regulated pathways of each miRNA were identified by microarray analyses. Target genes were validated by luciferase reporter assays and expression analyses in vitro. Furthermore, target gene expression was analyzed in 61 primary human HCCs compared to normal liver tissue. Tumor suppressive effects, binding specificities, target genes, and regulated pathways of miR-449a and miR-449b differed from those of miR-449c. Transfection of miR-449a, miR-449b, and/or miR-449c inhibited cell proliferation and migration, induced apoptosis, and reduced tumor growth to different extents. Importantly, miR-449a, miR-449b, and, to a lesser degree, miR-449c directly targeted SOX4, which codes for a transcription factor involved in epithelial-mesenchymal transition and HCC metastasis, and thereby inhibited TGF-β-mediated cell migration. This study provides detailed insights into the regulatory network of the epigenetically regulated miRNA-449 family and, for the first time, describes distinct tumor suppressive effects and target specificities of miR-449a, miR-449b, and miR-449c. Our results indicate that particularly miR-449a and miR-449b may be considered for miRNA replacement therapy to prevent HCC progression and metastasis. In this study, we demonstrated that the microRNA-449 family acts as a tumor suppressor in liver cancer by causing cell death and inhibiting cell migration. These effects are caused by downregulation of the oncogene SOX4, which is frequently overexpressed in liver cancer. We conclude that the microRNA-449 family may be a target for liver cancer therapy. [Display omitted] Modulation of microRNA expression is a potential treatment for hepatocellular carcinoma (HCC). Therefore, the epigenetically regulated microRNA-449 family (miR-449a, miR-449b, miR-449c) was characterized with regards to its functional effects and target genes in HCC. After transfection of miR-449a, miR-449b, and/or miR-449c, tumor-relevant functional effects were analyzed using in vitro assays and a xenograft mouse model. Binding specificities, target genes, and regulated pathways of each miRNA were identified by microarray analyses. Target genes were validated by luciferase reporter assays and expression analyses in vitro. Furthermore, target gene expression was analyzed in 61 primary human HCCs compared to normal liver tissue. Tumor suppressive effects, binding specificities, target genes, and regulated pathways of miR-449a and miR-449b differed from those of miR-449c. Transfection of miR-449a, miR-449b, and/or miR-449c inhibited cell proliferation and migration, induced apoptosis, and reduced tumor growth to different extents. Importantly, miR-449a, miR-449b, and, to a lesser degree, miR-449c directly targeted SOX4, which codes for a transcription factor involved in epithelial-mesenchymal transition and HCC metastasis, and thereby inhibited TGF-β-mediated cell migration. This study provides detailed insights into the regulatory network of the epigenetically regulated miRNA-449 family and, for the first time, describes distinct tumor suppressive effects and target specificities of miR-449a, miR-449b, and miR-449c. Our results indicate that particularly miR-449a and miR-449b may be considered for miRNA replacement therapy to prevent HCC progression and metastasis. In this study, we demonstrated that the microRNA-449 family acts as a tumor suppressor in liver cancer by causing cell death and inhibiting cell migration. These effects are caused by downregulation of the oncogene SOX4, which is frequently overexpressed in liver cancer. We conclude that the microRNA-449 family may be a target for liver cancer therapy. |
| Author | Kühnel, Florian Eilers, Marlies Longerich, Thomas Gürlevik, Engin Schlegelberger, Brigitte Buurman, Reena Vajen, Beate Illig, Thomas Sandbothe, Maria Reich, Nicole Greiwe, Luisa Schäffer, Vera Vaquero, Alejandro Manns, Michael P Skawran, Britta Schirmacher, Peter Roessler, Stephanie |
| Author_xml | – sequence: 1 fullname: Sandbothe, Maria – sequence: 2 fullname: Buurman, Reena – sequence: 3 fullname: Reich, Nicole – sequence: 4 fullname: Greiwe, Luisa – sequence: 5 fullname: Vajen, Beate – sequence: 6 fullname: Gürlevik, Engin – sequence: 7 fullname: Schäffer, Vera – sequence: 8 fullname: Eilers, Marlies – sequence: 9 fullname: Kühnel, Florian – sequence: 10 fullname: Vaquero, Alejandro – sequence: 11 fullname: Longerich, Thomas – sequence: 12 fullname: Roessler, Stephanie – sequence: 13 fullname: Schirmacher, Peter – sequence: 14 fullname: Manns, Michael P – sequence: 15 fullname: Illig, Thomas – sequence: 16 fullname: Schlegelberger, Brigitte – sequence: 17 fullname: Skawran, Britta |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28088579$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1u1DAUhS1URKeFF2CBsmST9F7HTmwJIVUVLZUqKtFBYoXl2M6MQ34GO1NpXosH4ZlwNIUFC1Znc87Rvd85IyfjNDpCXiMUCFhddEW3dbuCAtYFYAHAnpEVVgA5VAxPyCqZRC5oLU7JWYwdAJQg2QtySgUIwWu5It_WW5cN3oTp86fLnDGZtXrw_SHz49Y3fo7Z-uY6__UzH5z1enY26_2jC5nRo1nE9X2Kb4Ke_TRmzSGbddi42Y-b7OH-K3tJnre6j-7Vk56TL9cf1lcf87v7m9ury7vcMMQ5b2shmhJbIbGSllGBthGcW1a3tqZtRQ3nlaSylZUVCC2XptIl57IES01jy3Py9ti7C9OPvYuzGnxcjtOjm_ZRoaiQcxQlS1Z6tKafYwyuVbvgBx0OCkEtXFWnFq5q4aoAVeKaQm-e-vdNIvE38gdkMrw7Glz68tG7oKLxLjGyPjgzKzv5__e__yduej96o_vv7uBiN-3DmPgpVJEqUA_LssuwWJdpVSHL3-NynoA |
| CitedBy_id | crossref_primary_10_1080_21691401_2019_1610413 crossref_primary_10_1002_cam4_2469 crossref_primary_10_1038_s41389_019_0131_5 crossref_primary_10_1002_jcp_31076 crossref_primary_10_1186_s12935_022_02582_2 crossref_primary_10_31491_CSRC_2018_9_021 crossref_primary_10_1002_gcc_22982 crossref_primary_10_1016_j_bj_2020_08_009 crossref_primary_10_1186_s12958_017_0319_5 crossref_primary_10_1016_j_canlet_2021_12_033 crossref_primary_10_3892_ijo_2017_4038 crossref_primary_10_1093_molehr_gaaa016 crossref_primary_10_3892_etm_2018_6534 crossref_primary_10_3390_ani10091680 crossref_primary_10_1007_s43032_019_00097_2 crossref_primary_10_1080_17474124_2022_2101994 crossref_primary_10_1111_jcmm_14062 crossref_primary_10_1177_11779322241227722 crossref_primary_10_1016_j_cbi_2019_02_004 crossref_primary_10_3390_biology12010055 crossref_primary_10_1002_jcla_23009 crossref_primary_10_3390_life11121391 crossref_primary_10_2147_OTT_S283026 crossref_primary_10_1016_j_trecan_2017_06_002 crossref_primary_10_1177_1533034618765221 crossref_primary_10_1016_j_ygeno_2020_03_024 crossref_primary_10_3892_mmr_2018_9341 crossref_primary_10_1039_C9RA06129K crossref_primary_10_1038_s41419_021_03576_0 crossref_primary_10_3390_cancers14051165 crossref_primary_10_1038_s41598_019_56571_z crossref_primary_10_1016_j_biopha_2018_04_101 crossref_primary_10_1021_acsnano_3c09405 crossref_primary_10_1039_C9RA03608C crossref_primary_10_1111_jcmm_15088 crossref_primary_10_3390_ijms23147673 crossref_primary_10_1007_s12072_019_09967_y crossref_primary_10_1016_j_semcancer_2021_07_017 crossref_primary_10_1002_jcp_29918 crossref_primary_10_1016_j_gendis_2017_12_005 crossref_primary_10_1038_s41417_021_00348_y crossref_primary_10_1042_BSR20210126 crossref_primary_10_1002_jcp_28305 crossref_primary_10_1042_BCJ20160782 crossref_primary_10_1016_j_omtn_2019_01_007 crossref_primary_10_1038_s41598_017_13899_8 crossref_primary_10_1096_fj_201900522R crossref_primary_10_3390_cancers12092622 crossref_primary_10_1007_s12094_023_03164_y crossref_primary_10_1038_s41419_018_0732_5 crossref_primary_10_1016_j_bbrep_2023_101566 crossref_primary_10_1016_j_bbrc_2017_11_028 crossref_primary_10_1016_j_ejphar_2023_176071 crossref_primary_10_1166_jbt_2021_2680 crossref_primary_10_1007_s11626_019_00344_5 crossref_primary_10_1038_s41598_019_41472_y crossref_primary_10_3390_ijms23095131 crossref_primary_10_3892_ol_2018_8609 crossref_primary_10_1245_s10434_019_07227_9 crossref_primary_10_1002_mgg3_833 crossref_primary_10_5483_BMBRep_2020_53_5_219 crossref_primary_10_1016_j_bios_2021_113307 crossref_primary_10_1002_cnr2_1974 crossref_primary_10_1007_s00774_019_01080_2 crossref_primary_10_1080_21691401_2019_1637886 crossref_primary_10_1111_1759_7714_13450 crossref_primary_10_1016_j_biopha_2019_108652 crossref_primary_10_3390_ijms22010286 crossref_primary_10_3892_etm_2018_5836 crossref_primary_10_3892_ijmm_2019_4260 crossref_primary_10_1016_j_biopha_2018_11_029 crossref_primary_10_1016_j_prp_2018_10_007 crossref_primary_10_1186_s12868_022_00736_6 crossref_primary_10_3390_cancers13133287 crossref_primary_10_1016_j_omtn_2020_04_006 crossref_primary_10_1007_s12013_024_01322_9 crossref_primary_10_1016_j_yexmp_2019_04_011 crossref_primary_10_7717_peerj_9452 crossref_primary_10_3390_cells11132116 crossref_primary_10_1016_j_ymthe_2019_07_006 crossref_primary_10_1016_j_semcancer_2019_06_022 crossref_primary_10_1186_s12967_020_02279_y crossref_primary_10_1080_15384101_2017_1407894 crossref_primary_10_1097_CAD_0000000000000555 crossref_primary_10_2147_CMAR_S257598 crossref_primary_10_1021_acs_molpharmaceut_8b00046 crossref_primary_10_1166_sam_2023_4458 |
| Cites_doi | 10.1053/j.gastro.2012.05.033 10.1093/jmcb/mju003 10.1186/s12885-015-1738-3 10.1186/1758-907X-4-2 10.1002/hep.22033 10.1371/journal.pone.0072252 10.1016/j.jhep.2012.01.009 10.1111/liv.12097 10.1056/NEJMoa0708857 10.1016/j.cgh.2006.07.010 10.4103/0973-1482.137937 10.1038/cdd.2009.188 10.2174/138161212802430477 10.1016/j.jhep.2011.12.001 10.1371/journal.pone.0014460 10.1038/modpathol.2008.147 10.1016/j.canlet.2013.10.031 10.1101/gad.1819009 10.1038/onc.2008.168 10.1158/0008-5472.CAN-08-4043 10.1038/ng.3252 10.1038/modpathol.3800998 10.1038/nature13413 10.1016/j.bbrc.2014.08.124 10.1002/hep.25870 10.1186/1476-4598-10-29 10.1038/ncb2358 10.1073/pnas.1407777111 10.1038/nature05939 10.1016/j.ccr.2013.04.020 10.1093/carcin/bgq072 10.1016/j.canlet.2012.01.027 10.18632/oncotarget.4308 10.1016/j.cell.2009.01.002 10.1038/onc.2012.506 10.1002/ijc.29210 10.1016/j.febslet.2013.03.006 10.1038/onc.2009.19 10.4161/cc.6.13.4436 10.1016/j.ydbio.2015.05.012 10.1038/onc.2010.236 10.3389/fgene.2012.00120 10.1371/journal.pone.0053238 10.1016/j.biocel.2009.07.018 |
| ContentType | Journal Article |
| Copyright | 2017 European Association for the Study of the Liver Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2017 European Association for the Study of the Liver – notice: Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1016/j.jhep.2017.01.004 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1600-0641 |
| EndPage | 1021 |
| ExternalDocumentID | 10_1016_j_jhep_2017_01_004 28088579 S0168827817300089 1_s2_0_S0168827817300089 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | - 0R 1 1- 1B1 1P 1RT 1~. 1~5 29K 3O- 4.4 457 4G. 53G 55 5GY 5RE 5VS 7-5 71M 8P 9JM AABNK AACTN AAEDT AAIAV AAIKJ AAKOC AALMO AALRI AAOAW AAQFI AAQQT AAQXK AAXUO ABBQC ABFLS ABFNM ABFRF ABLVK ABMAC ABMZM ABPIF ABPTK ABQIS ABWYI ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADALY ADBBV ADEZE AEBSH AEFWE AEKER AENEX AEVXI AFCTW AFFNX AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AZFZN BKOJK BLXMC BNPGV CS3 D-I DU5 EBS EFJIC EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FO G- G-2 G-Q GBLVA GJ HDZ HMK HMO HVGLF HX HZ IHE IPNFZ J1W K KOM LCYCR LZ1 M M27 M41 MJL MO0 N9A O-L O9- OAUVE OC. ON0 OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSZ T5K TEORI UV1 WUQ X7M YOC Z5R ZGI --- --K --M .1- .55 .FO .GJ .~1 0R~ 1P~ 8P~ AAEDW ABJNI ADMUD AHPSJ AXJTR EFLBG FYGXN HX~ HZ~ ~G- AKRWK CGR CUY CVF ECM EIF NPM AAXKI AAYXX ADVLN CITATION 7X8 |
| ID | FETCH-LOGICAL-c411t-f788b31f89169d4281db855d47fd72f62c556929f96d810f59c6a355930d2cbd3 |
| IEDL.DBID | .~1 |
| ISSN | 0168-8278 |
| IngestDate | Tue Aug 27 04:16:56 EDT 2024 Thu Sep 12 18:04:07 EDT 2024 Thu May 23 23:25:02 EDT 2024 Fri Feb 23 02:32:16 EST 2024 Thu Aug 18 17:14:31 EDT 2022 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | transforming growth factor β small interfering RNA Metastasis microRNA replacement therapy complementary DNA Liver cancer miRNA TGF-β cDNA 3'UTR' hepatocellular carcinoma SOX4 microRNA family qRT-PCR HCC siRNA Histone acetylation quantitative real-time PCR histone deacetylase SRY (sex determining region Y)-box 4 3 untranslated region Epigenetics microRNA Cell migration HDAC |
| Language | English |
| License | Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c411t-f788b31f89169d4281db855d47fd72f62c556929f96d810f59c6a355930d2cbd3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 28088579 |
| PQID | 1861551834 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_1861551834 crossref_primary_10_1016_j_jhep_2017_01_004 pubmed_primary_28088579 elsevier_sciencedirect_doi_10_1016_j_jhep_2017_01_004 elsevier_clinicalkeyesjournals_1_s2_0_S0168827817300089 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-05-01 |
| PublicationDateYYYYMMDD | 2017-05-01 |
| PublicationDate_xml | – month: 05 year: 2017 text: 2017-05-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Journal of hepatology |
| PublicationTitleAlternate | J Hepatol |
| PublicationYear | 2017 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Vervoort, van Boxtel, Coffer (b0090) 2013; 32 Chen, Lin, Mao, Wu, Liu, Zheng (b0145) 2012; 320 Song, Walentek, Sponer, Klimke, Lee, Dixon (b0130) 2014; 510 Rasmussen, Jacobsen, Krogh (b0075) 2013; 4 He, He, Lim, de Stanchina, Xuan, Liang (b0110) 2007; 447 Yang, Feng, Jiang, Wu, Li, Aau (b0120) 2009; 23 Tarasov, Jung, Verdoodt, Lodygin, Epanchintsev, Menssen (b0115) 2007; 6 Marcet, Chevalier, Luxardi, Coraux, Zaragosi, Cibois (b0185) 2011; 13 Schulze, Imbeaud, Letouzé, Alexandrov, Calderaro, Rebouissou (b0210) 2015; 47 Reichl, Haider, Grubinger, Mikulits (b0215) 2012; 18 Skawran, Steinemann, Weigmann, Flemming, Becker, Flik (b0065) 2008; 21 Neumann, Kesselmeier, Geffers, Pellegrino, Radlwimmer, Hoffmann (b0070) 2012; 56 Serova, Tijeras-Raballand, Santos, Albuquerque, Paradis, Neuzillet (b0225) 2015; 6 Miao, Huang, Sun, Gao, Zhang, Liu (b0150) 2013; 587 Bader (b0040) 2012; 3 Lizé, Pilarski, Dobbelstein (b0125) 2010; 17 Hur, Rhim, Jung, Kim, Bae, Jang (b0195) 2010; 31 Ren, Yin, Zhang, Wang, Feng, Wang (b0155) 2014; 344 Skawran, Steinemann, Becker, Buurman, Flik, Wiese (b0060) 2008; 21 Lakshmaiah, Jacob, Aparna, Lokanatha, Saldanha (b0105) 2014; 10 Noonan, Place, Pookot, Basak, Whitson, Hirata (b0135) 2009; 28 Whittaker, Marais, Zhu (b0015) 2010; 29 Dzieran, Fabian, Feng, Coulouarn, Ilkavets, Kyselova (b0220) 2013; 8 Rokavec, Li, Jiang, Hermeking (b0045) 2014; 6 Vervoort, Lourenço, van Boxtel, Coffer (b0085) 2013; 8 Tiwari, Tiwari, Waldmeier, Balwierz, Arnold, Pachkov (b0080) 2013; 23 Bou Kheir, Futoma-Kazmierczak, Jacobsen, Krogh, Bardram, Hother (b0140) 2011; 10 Chen, Liu, Xu, Pei, Liao, Yuan (b0160) 2015; 15 Ferlay, Soerjomataram, Dikshit, Eser, Mathers, Rebelo (b0010) 2015; 136 Lachenmayer, Toffanin, Cabellos, Alsinet, Hoshida, Villanueva (b0100) 2012; 56 Bartel (b0030) 2009; 136 Liao, Sun, Chau, Chau, Lai, Wang (b0200) 2008; 27 Wu, Yang, Zhou, Zhang, Xie, Feng (b0095) 2010; 5 Penzo-Méndez (b0175) 2010; 42 Buurman, Gürlevik, Schäffer, Eilers, Sandbothe, Kreipe (b0035) 2012; 143 Steinemann, Skawran, Becker, Tauscher, Weigmann, Wingen (b0050) 2006; 4 Llovet, Ducreux (b0020) 2012; 56 Llovet, Ricci, Mazzaferro, Hilgard, Gane, Blanc (b0025) 2008; 359 Poncy, Antoniou, Cordi, Pierreux, Jacquemin, Lemaigre (b0180) 2015; 404 Wang, Zhang, Zhan, Lin, Yang, Hu (b0205) 2014; 452 Wu, Bao, Kim, Yuan, Tang, Zheng (b0190) 2014; 111 Schlaeger, Longerich, Schiller, Bewerunge, Mehrabi, Toedt (b0055) 2008; 47 Boyle, Levin (b0005) 2008 Dyrskjøt, Ostenfeld, Bramsen, Silahtaroglu, Lamy, Ramanathan (b0165) 2009; 69 Chen, Zhang, Zhang, Hao, Zhang, Zhang (b0170) 2013; 33 Whittaker (10.1016/j.jhep.2017.01.004_b0015) 2010; 29 Poncy (10.1016/j.jhep.2017.01.004_b0180) 2015; 404 Neumann (10.1016/j.jhep.2017.01.004_b0070) 2012; 56 Wang (10.1016/j.jhep.2017.01.004_b0205) 2014; 452 Skawran (10.1016/j.jhep.2017.01.004_b0065) 2008; 21 Vervoort (10.1016/j.jhep.2017.01.004_b0085) 2013; 8 Wu (10.1016/j.jhep.2017.01.004_b0095) 2010; 5 Reichl (10.1016/j.jhep.2017.01.004_b0215) 2012; 18 Tiwari (10.1016/j.jhep.2017.01.004_b0080) 2013; 23 Buurman (10.1016/j.jhep.2017.01.004_b0035) 2012; 143 Noonan (10.1016/j.jhep.2017.01.004_b0135) 2009; 28 Tarasov (10.1016/j.jhep.2017.01.004_b0115) 2007; 6 Hur (10.1016/j.jhep.2017.01.004_b0195) 2010; 31 Boyle (10.1016/j.jhep.2017.01.004_b0005) 2008 Skawran (10.1016/j.jhep.2017.01.004_b0060) 2008; 21 Llovet (10.1016/j.jhep.2017.01.004_b0025) 2008; 359 Penzo-Méndez (10.1016/j.jhep.2017.01.004_b0175) 2010; 42 Bartel (10.1016/j.jhep.2017.01.004_b0030) 2009; 136 Ferlay (10.1016/j.jhep.2017.01.004_b0010) 2015; 136 Dzieran (10.1016/j.jhep.2017.01.004_b0220) 2013; 8 Lachenmayer (10.1016/j.jhep.2017.01.004_b0100) 2012; 56 Lakshmaiah (10.1016/j.jhep.2017.01.004_b0105) 2014; 10 Ren (10.1016/j.jhep.2017.01.004_b0155) 2014; 344 Lizé (10.1016/j.jhep.2017.01.004_b0125) 2010; 17 Vervoort (10.1016/j.jhep.2017.01.004_b0090) 2013; 32 Llovet (10.1016/j.jhep.2017.01.004_b0020) 2012; 56 Schlaeger (10.1016/j.jhep.2017.01.004_b0055) 2008; 47 Rasmussen (10.1016/j.jhep.2017.01.004_b0075) 2013; 4 Chen (10.1016/j.jhep.2017.01.004_b0170) 2013; 33 Schulze (10.1016/j.jhep.2017.01.004_b0210) 2015; 47 Miao (10.1016/j.jhep.2017.01.004_b0150) 2013; 587 Chen (10.1016/j.jhep.2017.01.004_b0160) 2015; 15 Marcet (10.1016/j.jhep.2017.01.004_b0185) 2011; 13 Steinemann (10.1016/j.jhep.2017.01.004_b0050) 2006; 4 Yang (10.1016/j.jhep.2017.01.004_b0120) 2009; 23 Bader (10.1016/j.jhep.2017.01.004_b0040) 2012; 3 Chen (10.1016/j.jhep.2017.01.004_b0145) 2012; 320 Bou Kheir (10.1016/j.jhep.2017.01.004_b0140) 2011; 10 He (10.1016/j.jhep.2017.01.004_b0110) 2007; 447 Rokavec (10.1016/j.jhep.2017.01.004_b0045) 2014; 6 Dyrskjøt (10.1016/j.jhep.2017.01.004_b0165) 2009; 69 Wu (10.1016/j.jhep.2017.01.004_b0190) 2014; 111 Song (10.1016/j.jhep.2017.01.004_b0130) 2014; 510 Liao (10.1016/j.jhep.2017.01.004_b0200) 2008; 27 Serova (10.1016/j.jhep.2017.01.004_b0225) 2015; 6 |
| References_xml | – volume: 143 start-page: 811 year: 2012 end-page: 820 ident: b0035 article-title: Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells publication-title: Gastroenterology contributor: fullname: Kreipe – volume: 344 start-page: 195 year: 2014 end-page: 203 ident: b0155 article-title: Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells publication-title: Cancer Lett contributor: fullname: Wang – volume: 23 start-page: 2388 year: 2009 end-page: 2393 ident: b0120 article-title: MiR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A publication-title: Genes Dev contributor: fullname: Aau – volume: 587 start-page: 1359 year: 2013 end-page: 1365 ident: b0150 article-title: MiR-449c targets c-Myc and inhibits NSCLC cell progression publication-title: FEBS Lett contributor: fullname: Liu – volume: 404 start-page: 136 year: 2015 end-page: 148 ident: b0180 article-title: Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts publication-title: Dev Biol contributor: fullname: Lemaigre – volume: 47 start-page: 511 year: 2008 end-page: 520 ident: b0055 article-title: Etiology-dependent molecular mechanisms in human hepatocarcinogenesis publication-title: Hepatology contributor: fullname: Toedt – volume: 21 start-page: 1479 year: 2008 end-page: 1489 ident: b0060 article-title: Loss of 13q is associated with genes involved in cell cycle and proliferation in dedifferentiated hepatocellular carcinoma publication-title: Mod Pathol contributor: fullname: Wiese – volume: 6 start-page: 1586 year: 2007 end-page: 1593 ident: b0115 article-title: Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest publication-title: Cell Cycle contributor: fullname: Menssen – volume: 42 start-page: 425 year: 2010 end-page: 428 ident: b0175 article-title: Critical roles for SoxC transcription factors in development and cancer publication-title: Int J Biochem Cell Biol contributor: fullname: Penzo-Méndez – volume: 8 year: 2013 ident: b0085 article-title: SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition publication-title: PLoS One contributor: fullname: Coffer – volume: 111 start-page: E2851 year: 2014 end-page: E2857 ident: b0190 article-title: Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis publication-title: Proc Natl Acad Sci U S A contributor: fullname: Zheng – volume: 6 start-page: 214 year: 2014 end-page: 230 ident: b0045 article-title: The p53/miR-34 axis in development and disease publication-title: J Mol Cell Biol contributor: fullname: Hermeking – year: 2008 ident: b0005 article-title: International agency for research on cancer publication-title: World cancer report 2008 contributor: fullname: Levin – volume: 31 start-page: 1298 year: 2010 end-page: 1307 ident: b0195 article-title: SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro publication-title: Carcinogenesis contributor: fullname: Jang – volume: 17 start-page: 452 year: 2010 end-page: 458 ident: b0125 article-title: E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis publication-title: Cell Death Differ contributor: fullname: Dobbelstein – volume: 69 start-page: 4851 year: 2009 end-page: 4860 ident: b0165 article-title: Genomic profiling of MicroRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro publication-title: Cancer Res contributor: fullname: Ramanathan – volume: 47 start-page: 505 year: 2015 end-page: 511 ident: b0210 article-title: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets publication-title: Nat Genet contributor: fullname: Rebouissou – volume: 33 start-page: 476 year: 2013 end-page: 486 ident: b0170 article-title: Methylation-mediated repression of microRNA 129–2 enhances oncogenic SOX4 expression in HCC publication-title: Liver Int contributor: fullname: Zhang – volume: 27 start-page: 5578 year: 2008 end-page: 5589 ident: b0200 article-title: Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma publication-title: Oncogene contributor: fullname: Wang – volume: 3 start-page: 120 year: 2012 ident: b0040 article-title: MiR-34 – a microRNA replacement therapy is headed to the clinic publication-title: Front Genet contributor: fullname: Bader – volume: 23 start-page: 768 year: 2013 end-page: 783 ident: b0080 article-title: Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming publication-title: Cancer Cell contributor: fullname: Pachkov – volume: 32 start-page: 3397 year: 2013 end-page: 3409 ident: b0090 article-title: The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe? publication-title: Oncogene contributor: fullname: Coffer – volume: 136 start-page: 215 year: 2009 end-page: 233 ident: b0030 article-title: MicroRNAs: target recognition and regulatory functions publication-title: Cell contributor: fullname: Bartel – volume: 56 start-page: 1343 year: 2012 end-page: 1350 ident: b0100 article-title: Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib publication-title: J Hepatol contributor: fullname: Villanueva – volume: 56 start-page: 908 year: 2012 end-page: 943 ident: b0020 article-title: EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma publication-title: J Hepatol contributor: fullname: Ducreux – volume: 29 start-page: 4989 year: 2010 end-page: 5005 ident: b0015 article-title: The role of signaling pathways in the development and treatment of hepatocellular carcinoma publication-title: Oncogene contributor: fullname: Zhu – volume: 359 start-page: 378 year: 2008 end-page: 390 ident: b0025 article-title: Sorafenib in advanced hepatocellular carcinoma publication-title: N Engl J Med contributor: fullname: Blanc – volume: 10 start-page: 469 year: 2014 end-page: 478 ident: b0105 article-title: Epigenetic therapy of cancer with histone deacetylase inhibitors publication-title: J Cancer Res Ther contributor: fullname: Saldanha – volume: 56 start-page: 1817 year: 2012 end-page: 1827 ident: b0070 article-title: Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors publication-title: Hepatology contributor: fullname: Hoffmann – volume: 4 start-page: 1283 year: 2006 end-page: 1291 ident: b0050 article-title: Assessment of differentiation and progression of hepatic tumors using array-based comparative genomic hybridization publication-title: Clin Gastroenterol Hepatol contributor: fullname: Wingen – volume: 5 year: 2010 ident: b0095 article-title: Identification of histone deacetylase 3 as a biomarker for tumor recurrence following liver transplantation in HBV-associated hepatocellular carcinoma publication-title: PLoS One contributor: fullname: Feng – volume: 8 year: 2013 ident: b0220 article-title: Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines publication-title: PLoS One contributor: fullname: Kyselova – volume: 6 start-page: 21614 year: 2015 end-page: 21627 ident: b0225 article-title: Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients publication-title: Oncotarget contributor: fullname: Neuzillet – volume: 4 start-page: 2 year: 2013 ident: b0075 article-title: CWords – systematic microRNA regulatory motif discovery from mRNA expression data publication-title: Silence contributor: fullname: Krogh – volume: 15 start-page: 706 year: 2015 ident: b0160 article-title: MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets publication-title: BMC Cancer contributor: fullname: Yuan – volume: 28 start-page: 1714 year: 2009 end-page: 1724 ident: b0135 article-title: MiR-449a targets HDAC-1 and induces growth arrest in prostate cancer publication-title: Oncogene contributor: fullname: Hirata – volume: 13 start-page: 693 year: 2011 end-page: 699 ident: b0185 article-title: Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway publication-title: Nat Cell Biol contributor: fullname: Cibois – volume: 447 start-page: 1130 year: 2007 end-page: 1134 ident: b0110 article-title: A microRNA component of the p53 tumour suppressor network publication-title: Nature contributor: fullname: Liang – volume: 136 start-page: E359 year: 2015 end-page: E386 ident: b0010 article-title: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 publication-title: Int J Cancer contributor: fullname: Rebelo – volume: 21 start-page: 505 year: 2008 end-page: 516 ident: b0065 article-title: Gene expression profiling in hepatocellular carcinoma: upregulation of genes in amplified chromosome regions publication-title: Mod Pathol contributor: fullname: Flik – volume: 510 start-page: 115 year: 2014 end-page: 120 ident: b0130 article-title: MiR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110 publication-title: Nature contributor: fullname: Dixon – volume: 18 start-page: 4135 year: 2012 end-page: 4147 ident: b0215 article-title: TGF-β in epithelial to mesenchymal transition and metastasis of liver carcinoma publication-title: Curr Pharm Des contributor: fullname: Mikulits – volume: 10 start-page: 29 year: 2011 ident: b0140 article-title: MiR-449 inhibits cell proliferation and is down-regulated in gastric cancer publication-title: Mol Cancer contributor: fullname: Hother – volume: 320 start-page: 40 year: 2012 end-page: 47 ident: b0145 article-title: MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins publication-title: Cancer Lett contributor: fullname: Zheng – volume: 452 start-page: 614 year: 2014 end-page: 621 ident: b0205 article-title: SOX4 is associated with poor prognosis in cholangiocarcinoma publication-title: Biochem Biophys Res Commun contributor: fullname: Hu – volume: 143 start-page: 811 year: 2012 ident: 10.1016/j.jhep.2017.01.004_b0035 article-title: Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells publication-title: Gastroenterology doi: 10.1053/j.gastro.2012.05.033 contributor: fullname: Buurman – volume: 6 start-page: 214 year: 2014 ident: 10.1016/j.jhep.2017.01.004_b0045 article-title: The p53/miR-34 axis in development and disease publication-title: J Mol Cell Biol doi: 10.1093/jmcb/mju003 contributor: fullname: Rokavec – volume: 15 start-page: 706 year: 2015 ident: 10.1016/j.jhep.2017.01.004_b0160 article-title: MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets publication-title: BMC Cancer doi: 10.1186/s12885-015-1738-3 contributor: fullname: Chen – volume: 4 start-page: 2 year: 2013 ident: 10.1016/j.jhep.2017.01.004_b0075 article-title: CWords – systematic microRNA regulatory motif discovery from mRNA expression data publication-title: Silence doi: 10.1186/1758-907X-4-2 contributor: fullname: Rasmussen – volume: 47 start-page: 511 year: 2008 ident: 10.1016/j.jhep.2017.01.004_b0055 article-title: Etiology-dependent molecular mechanisms in human hepatocarcinogenesis publication-title: Hepatology doi: 10.1002/hep.22033 contributor: fullname: Schlaeger – volume: 8 year: 2013 ident: 10.1016/j.jhep.2017.01.004_b0220 article-title: Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines publication-title: PLoS One doi: 10.1371/journal.pone.0072252 contributor: fullname: Dzieran – volume: 56 start-page: 1343 year: 2012 ident: 10.1016/j.jhep.2017.01.004_b0100 article-title: Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib publication-title: J Hepatol doi: 10.1016/j.jhep.2012.01.009 contributor: fullname: Lachenmayer – volume: 33 start-page: 476 year: 2013 ident: 10.1016/j.jhep.2017.01.004_b0170 article-title: Methylation-mediated repression of microRNA 129–2 enhances oncogenic SOX4 expression in HCC publication-title: Liver Int doi: 10.1111/liv.12097 contributor: fullname: Chen – volume: 359 start-page: 378 year: 2008 ident: 10.1016/j.jhep.2017.01.004_b0025 article-title: Sorafenib in advanced hepatocellular carcinoma publication-title: N Engl J Med doi: 10.1056/NEJMoa0708857 contributor: fullname: Llovet – volume: 4 start-page: 1283 year: 2006 ident: 10.1016/j.jhep.2017.01.004_b0050 article-title: Assessment of differentiation and progression of hepatic tumors using array-based comparative genomic hybridization publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2006.07.010 contributor: fullname: Steinemann – volume: 10 start-page: 469 year: 2014 ident: 10.1016/j.jhep.2017.01.004_b0105 article-title: Epigenetic therapy of cancer with histone deacetylase inhibitors publication-title: J Cancer Res Ther doi: 10.4103/0973-1482.137937 contributor: fullname: Lakshmaiah – volume: 17 start-page: 452 year: 2010 ident: 10.1016/j.jhep.2017.01.004_b0125 article-title: E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis publication-title: Cell Death Differ doi: 10.1038/cdd.2009.188 contributor: fullname: Lizé – volume: 18 start-page: 4135 year: 2012 ident: 10.1016/j.jhep.2017.01.004_b0215 article-title: TGF-β in epithelial to mesenchymal transition and metastasis of liver carcinoma publication-title: Curr Pharm Des doi: 10.2174/138161212802430477 contributor: fullname: Reichl – volume: 56 start-page: 908 year: 2012 ident: 10.1016/j.jhep.2017.01.004_b0020 article-title: EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma publication-title: J Hepatol doi: 10.1016/j.jhep.2011.12.001 contributor: fullname: Llovet – volume: 5 year: 2010 ident: 10.1016/j.jhep.2017.01.004_b0095 article-title: Identification of histone deacetylase 3 as a biomarker for tumor recurrence following liver transplantation in HBV-associated hepatocellular carcinoma publication-title: PLoS One doi: 10.1371/journal.pone.0014460 contributor: fullname: Wu – volume: 21 start-page: 1479 year: 2008 ident: 10.1016/j.jhep.2017.01.004_b0060 article-title: Loss of 13q is associated with genes involved in cell cycle and proliferation in dedifferentiated hepatocellular carcinoma publication-title: Mod Pathol doi: 10.1038/modpathol.2008.147 contributor: fullname: Skawran – volume: 344 start-page: 195 year: 2014 ident: 10.1016/j.jhep.2017.01.004_b0155 article-title: Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells publication-title: Cancer Lett doi: 10.1016/j.canlet.2013.10.031 contributor: fullname: Ren – volume: 23 start-page: 2388 year: 2009 ident: 10.1016/j.jhep.2017.01.004_b0120 article-title: MiR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A publication-title: Genes Dev doi: 10.1101/gad.1819009 contributor: fullname: Yang – volume: 27 start-page: 5578 year: 2008 ident: 10.1016/j.jhep.2017.01.004_b0200 article-title: Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma publication-title: Oncogene doi: 10.1038/onc.2008.168 contributor: fullname: Liao – volume: 69 start-page: 4851 year: 2009 ident: 10.1016/j.jhep.2017.01.004_b0165 article-title: Genomic profiling of MicroRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-4043 contributor: fullname: Dyrskjøt – volume: 47 start-page: 505 year: 2015 ident: 10.1016/j.jhep.2017.01.004_b0210 article-title: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets publication-title: Nat Genet doi: 10.1038/ng.3252 contributor: fullname: Schulze – volume: 21 start-page: 505 year: 2008 ident: 10.1016/j.jhep.2017.01.004_b0065 article-title: Gene expression profiling in hepatocellular carcinoma: upregulation of genes in amplified chromosome regions publication-title: Mod Pathol doi: 10.1038/modpathol.3800998 contributor: fullname: Skawran – volume: 510 start-page: 115 year: 2014 ident: 10.1016/j.jhep.2017.01.004_b0130 article-title: MiR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110 publication-title: Nature doi: 10.1038/nature13413 contributor: fullname: Song – volume: 452 start-page: 614 year: 2014 ident: 10.1016/j.jhep.2017.01.004_b0205 article-title: SOX4 is associated with poor prognosis in cholangiocarcinoma publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2014.08.124 contributor: fullname: Wang – volume: 56 start-page: 1817 year: 2012 ident: 10.1016/j.jhep.2017.01.004_b0070 article-title: Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors publication-title: Hepatology doi: 10.1002/hep.25870 contributor: fullname: Neumann – volume: 10 start-page: 29 year: 2011 ident: 10.1016/j.jhep.2017.01.004_b0140 article-title: MiR-449 inhibits cell proliferation and is down-regulated in gastric cancer publication-title: Mol Cancer doi: 10.1186/1476-4598-10-29 contributor: fullname: Bou Kheir – volume: 13 start-page: 693 year: 2011 ident: 10.1016/j.jhep.2017.01.004_b0185 article-title: Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway publication-title: Nat Cell Biol doi: 10.1038/ncb2358 contributor: fullname: Marcet – volume: 111 start-page: E2851 year: 2014 ident: 10.1016/j.jhep.2017.01.004_b0190 article-title: Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1407777111 contributor: fullname: Wu – volume: 447 start-page: 1130 year: 2007 ident: 10.1016/j.jhep.2017.01.004_b0110 article-title: A microRNA component of the p53 tumour suppressor network publication-title: Nature doi: 10.1038/nature05939 contributor: fullname: He – volume: 23 start-page: 768 year: 2013 ident: 10.1016/j.jhep.2017.01.004_b0080 article-title: Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming publication-title: Cancer Cell doi: 10.1016/j.ccr.2013.04.020 contributor: fullname: Tiwari – volume: 31 start-page: 1298 year: 2010 ident: 10.1016/j.jhep.2017.01.004_b0195 article-title: SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro publication-title: Carcinogenesis doi: 10.1093/carcin/bgq072 contributor: fullname: Hur – volume: 320 start-page: 40 year: 2012 ident: 10.1016/j.jhep.2017.01.004_b0145 article-title: MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins publication-title: Cancer Lett doi: 10.1016/j.canlet.2012.01.027 contributor: fullname: Chen – volume: 6 start-page: 21614 year: 2015 ident: 10.1016/j.jhep.2017.01.004_b0225 article-title: Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients publication-title: Oncotarget doi: 10.18632/oncotarget.4308 contributor: fullname: Serova – volume: 136 start-page: 215 year: 2009 ident: 10.1016/j.jhep.2017.01.004_b0030 article-title: MicroRNAs: target recognition and regulatory functions publication-title: Cell doi: 10.1016/j.cell.2009.01.002 contributor: fullname: Bartel – volume: 32 start-page: 3397 year: 2013 ident: 10.1016/j.jhep.2017.01.004_b0090 article-title: The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe? publication-title: Oncogene doi: 10.1038/onc.2012.506 contributor: fullname: Vervoort – volume: 136 start-page: E359 year: 2015 ident: 10.1016/j.jhep.2017.01.004_b0010 article-title: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 publication-title: Int J Cancer doi: 10.1002/ijc.29210 contributor: fullname: Ferlay – volume: 587 start-page: 1359 year: 2013 ident: 10.1016/j.jhep.2017.01.004_b0150 article-title: MiR-449c targets c-Myc and inhibits NSCLC cell progression publication-title: FEBS Lett doi: 10.1016/j.febslet.2013.03.006 contributor: fullname: Miao – volume: 28 start-page: 1714 year: 2009 ident: 10.1016/j.jhep.2017.01.004_b0135 article-title: MiR-449a targets HDAC-1 and induces growth arrest in prostate cancer publication-title: Oncogene doi: 10.1038/onc.2009.19 contributor: fullname: Noonan – volume: 6 start-page: 1586 year: 2007 ident: 10.1016/j.jhep.2017.01.004_b0115 article-title: Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest publication-title: Cell Cycle doi: 10.4161/cc.6.13.4436 contributor: fullname: Tarasov – volume: 404 start-page: 136 year: 2015 ident: 10.1016/j.jhep.2017.01.004_b0180 article-title: Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts publication-title: Dev Biol doi: 10.1016/j.ydbio.2015.05.012 contributor: fullname: Poncy – volume: 29 start-page: 4989 year: 2010 ident: 10.1016/j.jhep.2017.01.004_b0015 article-title: The role of signaling pathways in the development and treatment of hepatocellular carcinoma publication-title: Oncogene doi: 10.1038/onc.2010.236 contributor: fullname: Whittaker – year: 2008 ident: 10.1016/j.jhep.2017.01.004_b0005 article-title: International agency for research on cancer contributor: fullname: Boyle – volume: 3 start-page: 120 year: 2012 ident: 10.1016/j.jhep.2017.01.004_b0040 article-title: MiR-34 – a microRNA replacement therapy is headed to the clinic publication-title: Front Genet doi: 10.3389/fgene.2012.00120 contributor: fullname: Bader – volume: 8 year: 2013 ident: 10.1016/j.jhep.2017.01.004_b0085 article-title: SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition publication-title: PLoS One doi: 10.1371/journal.pone.0053238 contributor: fullname: Vervoort – volume: 42 start-page: 425 year: 2010 ident: 10.1016/j.jhep.2017.01.004_b0175 article-title: Critical roles for SoxC transcription factors in development and cancer publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2009.07.018 contributor: fullname: Penzo-Méndez |
| SSID | ssj0003094 |
| Score | 2.5693517 |
| Snippet | Graphical abstract [Display omitted] Modulation of microRNA expression is a potential treatment for hepatocellular carcinoma (HCC). Therefore, the epigenetically regulated... Modulation of microRNA expression is a potential treatment for hepatocellular carcinoma (HCC). Therefore, the epigenetically regulated microRNA-449 family... BACKGROUND & AIMSModulation of microRNA expression is a potential treatment for hepatocellular carcinoma (HCC). Therefore, the epigenetically regulated... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 1012 |
| SubjectTerms | Acetylation Animals Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Cell migration Cell Movement Epigenetics Gastroenterology and Hepatology Genes, Tumor Suppressor - physiology Histone acetylation Histones - metabolism Humans Liver cancer Liver Neoplasms - pathology Liver Neoplasms - therapy Metastasis Mice microRNA family microRNA replacement therapy MicroRNAs - physiology SOXC Transcription Factors - genetics Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - physiology |
| Title | The microRNA-449 family inhibits TGF-β-mediated liver cancer cell migration by targeting SOX4 |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0168827817300089 https://dx.doi.org/10.1016/j.jhep.2017.01.004 https://www.ncbi.nlm.nih.gov/pubmed/28088579 https://search.proquest.com/docview/1861551834 |
| Volume | 66 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9wgEEZRKkW9VG3Tx_YRESm3ii7YgOG4irrdJspGahJpT0XGQOJo60TdzaGX_qj-kP6mDganqvo45GTZAmHPDDMf-JsBob3gYblW14xUofCEywb8oPaWFDZUljOrLY0JzkdzOTvjBwux2ED7Qy5MpFVm3598eu-t85Nxlub4um3HJwBWAB5WisWS61TFJD4OwQhs-u23XzSPkupc31uR2DonziSO1-WFjzUrWdWX7syHtf0lOP0LfPZBaPoQPcjoEU_SCz5CG757jLaO8v_xbfQJtI4_R47dx_mEcK5x2sDAbXfR2na9wqfvp-THd9InjADYxMvIy8BN1D1c_HIJ3c-TVWD7FSeiOIQ3fHK84E_Q2fTd6f6M5BMUSMMZW5MAC1xbsqAABGoHKw3mrBLC8Sq4qgiyaISQAJCClk4xGoRuZA0IRJfUFY115VO02V11_jnC1DrZAF4rvYPAB-qlhRO1dkEJ70MtR-jNIDpznQplmIFBdmmioE0UtKHMgKBHqBqka4YUUHBafpVn0MowsyoMNX9oeYTEbc_fDMVADPjviLuDEg3MoCjQuvNXNzCSkn1duhLaPEvavf2CQoEXFpV-ccdRX6L78S4xJF-hzfWXG_8aUMza7vRmuoPuTT4czuY_Ado178E |
| link.rule.ids | 315,786,790,4521,24144,27957,27958,45620,45714 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLVGJwEvaHwXBhiJN2TVTuzEfqymdR1bi8Q6qU9YcWxvmUo20e6Bv8UP4TdxHTuVEB8PPEVKYjm51z73ODn3GqF33sFyraoYKX3mCC9qwEHlDMmMLw1nRhkaEpxn82J6zj8sxXIHHfS5MEFWmbA_YnqH1unMKFlzdNM0ozMgK0APS8lCyXUq1R20y0XJ-ADtjo9PpvMtIOdUpRLfkoQGKXcmyryuLl0oW8nKrnpn2q_tD_Hpb_yzi0OTPfQgEUg8js_4EO249hG6O0u_yB-jz-B4_CXI7D7Nx4RzheM3DNy0l41pNmu8OJqQH99JlzMCfBOvgjQD18H9cHCrFTS_iAMDm284asUhwuGzj0v-BJ1PDhcHU5I2USA1Z2xDPKxxTc68BB6oLCw2mDVSCMtLb8vMF1ktRAEcyavCSka9UHVRAQlRObVZbWz-FA3a69Y9R5gaW9RA2XJnIfaBh2lmRaWsl8I5XxVD9L43nb6JtTJ0LyK70sHQOhhaU6bB0ENU9tbVfRYo4JZbp0m01kyvM031b44eIrFt-ctY0RAG_tnj296JGiZRMGjVuutb6EkWXWm6HO55Fr27fYNMAhCLUr34z17foHvTxexUnx7PT16i--FKFEzuo8Hm6617BaRmY16nQfsTKGHydw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+microRNA-449+family+inhibits+TGF-%CE%B2-mediated+liver+cancer+cell+migration+by+targeting+SOX4&rft.jtitle=Journal+of+hepatology&rft.au=Sandbothe%2C+Maria&rft.au=Buurman%2C+Reena&rft.au=Reich%2C+Nicole&rft.au=Greiwe%2C+Luisa&rft.date=2017-05-01&rft.issn=0168-8278&rft.eissn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2017.01.004&rft.externalDocID=1_s2_0_S0168827817300089 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0168-8278&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0168-8278&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0168-8278&client=summon |