The microRNA-449 family inhibits TGF-β-mediated liver cancer cell migration by targeting SOX4

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Bibliographic Details
Published inJournal of hepatology Vol. 66; no. 5; pp. 1012 - 1021
Main Authors Sandbothe, Maria, Buurman, Reena, Reich, Nicole, Greiwe, Luisa, Vajen, Beate, Gürlevik, Engin, Schäffer, Vera, Eilers, Marlies, Kühnel, Florian, Vaquero, Alejandro, Longerich, Thomas, Roessler, Stephanie, Schirmacher, Peter, Manns, Michael P, Illig, Thomas, Schlegelberger, Brigitte, Skawran, Britta
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.05.2017
Subjects
Acetylation
Animals
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Cell migration
Cell Movement
Epigenetics
Gastroenterology and Hepatology
Genes, Tumor Suppressor - physiology
Histone acetylation
Histones - metabolism
Humans
Liver cancer
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Metastasis
Mice
microRNA family
microRNA replacement therapy
MicroRNAs - physiology
SOXC Transcription Factors - genetics
Transforming Growth Factor beta - antagonists & inhibitors
Transforming Growth Factor beta - physiology
transforming growth factor β
small interfering RNA
Metastasis
microRNA replacement therapy
complementary DNA
Liver cancer
miRNA
TGF-β
cDNA
3'UTR'
hepatocellular carcinoma
SOX4
microRNA family
qRT-PCR
HCC
siRNA
Histone acetylation
quantitative real-time PCR
histone deacetylase
SRY (sex determining region Y)-box 4
3 untranslated region
Epigenetics
microRNA
Cell migration
HDAC
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Summary:Graphical abstract
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2017.01.004