The Myeloprotective Effect of Medroxyprogesterone Acetate in an Irradiated Animal Model

Background: In this study we evaluated the effect of medroxyprogesterone acetate (MPA) and its major ingredients on protection of the hematopoietic organs against radiation damage. Method: One group of mice was given saline as placebo and the other groups were given MPA. Mice were injected with MPA...

Full description

Saved in:
Bibliographic Details
Published inJapanese journal of clinical oncology Vol. 33; no. 12; pp. 642 - 644
Main Authors Sarper, Binnaz Celebioglu, Kurtman, Cengiz, Ozbilgin, M. Kemal
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.12.2003
Oxford Publishing Limited (England)
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Background: In this study we evaluated the effect of medroxyprogesterone acetate (MPA) and its major ingredients on protection of the hematopoietic organs against radiation damage. Method: One group of mice was given saline as placebo and the other groups were given MPA. Mice were injected with MPA (10 mg/kg) or saline 10 days before or after a single 8 Gy whole body cobalt irradiation. On day 14 the mice were sacrificed and their bone marrow transplanted to recipient mice. Ten days after the transplantation, spleen colony formation was investigated in mice. Results: Administration of MPA with irradiation increased the formation of the spleen colony. Statistically significant enhancement of the spleen colony formation was found in mice treated with MPA repeatedly, as compared with those treated with placebo (P < 0.001). No significant difference in Spleen Colony Forming Unit (CFU-S) numbers was observed between pre-and post-radiotherapy administration of MPA (P = 0.216). Conclusion: It is an important observation that no significant difference was observed in CFU-S numbers between pre- and post-irradiation administration of MPA.
Bibliography:Received September 1, 2003; accepted November 7, 2003
istex:4A589D8889AA4BEB7B4093112C19F1F678306B50
ark:/67375/HXZ-FV1P4L6L-2
local:hyg122
ISSN:0368-2811
1465-3621
1465-3621
DOI:10.1093/jjco/hyg122