Systemic availability of oral slow-release morphine in man

In a within-patient crossover study on twelve patients we investigated plasma morphine concentrations for 48 hours after administration of intravenous morphine sulphate followed 24 hours later by oral MST Continus [MST]. Patients received either 10 mg i.v. morphine followed by 10 mg MST or 20 mg i.v...

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Bibliographic Details
Published inAnnals of clinical biochemistry Vol. 22 ( Pt 3); p. 226
Main Authors Moore, R A, McQuay, H J, Bullingham, R E, Baldwin, D, Allen, M C
Format Journal Article
LanguageEnglish
Published England 01.05.1985
Subjects
Administration, Oral
Biological Availability
Delayed-Action Preparations
Humans
Injections, Intravenous
Liver - metabolism
Morphine - administration & dosage
Morphine - blood
Morphine - metabolism
Pain - drug therapy
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Summary:In a within-patient crossover study on twelve patients we investigated plasma morphine concentrations for 48 hours after administration of intravenous morphine sulphate followed 24 hours later by oral MST Continus [MST]. Patients received either 10 mg i.v. morphine followed by 10 mg MST or 20 mg i.v. morphine followed by 2 X 10 mg MST tablets. Systemic clearance of morphine was low, being about 3 ml/min/kg after both intravenous and oral administration. The ratio of the areas under the concentration-time curve for MST relative to that for i.v. morphine was about 1:1 for 20 mg doses, but was significantly greater than 1:1 for 10 mg doses. The results suggest high oral systemic availability for morphine and low hepatic morphine metabolism.
ISSN:0004-5632
DOI:10.1177/000456328502200303