Systemic availability of oral slow-release morphine in man
In a within-patient crossover study on twelve patients we investigated plasma morphine concentrations for 48 hours after administration of intravenous morphine sulphate followed 24 hours later by oral MST Continus [MST]. Patients received either 10 mg i.v. morphine followed by 10 mg MST or 20 mg i.v...
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Published in | Annals of clinical biochemistry Vol. 22 ( Pt 3); p. 226 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.05.1985
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Subjects | |
Online Access | Get more information |
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Summary: | In a within-patient crossover study on twelve patients we investigated plasma morphine concentrations for 48 hours after administration of intravenous morphine sulphate followed 24 hours later by oral MST Continus [MST]. Patients received either 10 mg i.v. morphine followed by 10 mg MST or 20 mg i.v. morphine followed by 2 X 10 mg MST tablets. Systemic clearance of morphine was low, being about 3 ml/min/kg after both intravenous and oral administration. The ratio of the areas under the concentration-time curve for MST relative to that for i.v. morphine was about 1:1 for 20 mg doses, but was significantly greater than 1:1 for 10 mg doses. The results suggest high oral systemic availability for morphine and low hepatic morphine metabolism. |
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ISSN: | 0004-5632 |
DOI: | 10.1177/000456328502200303 |