Trachylobane and kaurane diterpenes from Croton floribundus spreng

A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-di...

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Published inQuímica Nova Vol. 36; no. 6; pp. 778 - 782
Main Authors Uchôa, Paula Karina S., Silva Jr, José Nunes da, Silveira, Edilberto Rocha, Lima, Mary Anne S., Braz-Filho, Raimundo, Costa-Lotufo, Letícia Veras, Araújo, Ana Jérsia, Moraes, Manoel Odorico de, Pessoa, Claudia do Ó
Format Journal Article
LanguageEnglish
Published Sociedade Brasileira de Química 2013
Subjects
Croton floribundus
diterpenes
Euphorbiaceae
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Summary:A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively.
ISSN:0100-4042
1678-7064
DOI:10.1590/S0100-40422013000600006