Steroid-responsive bronchiolitis after human heart-lung transplantation

This report describes the clinical course of a patient who developed obliterative bronchiolitis after viral infection on three separate occasions. Long-term follow-up is given. It is suggested that the syndrome of late pulmonary deterioration after transplantation may be steroid responsive if treatm...

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Published inThe Journal of thoracic and cardiovascular surgery Vol. 92; no. 3; pp. 449 - 451
Main Authors Allen, MD, Burke, CM, McGregor, CG, Baldwin, JC, Jamieson, SW, Theodore, J
Format Journal Article
LanguageEnglish
Published Philadelphia, PA AATS/WTSA 01.09.1986
Elsevier
Subjects
Adult
Analytical, structural and metabolic biochemistry
Avian Sarcoma Viruses
Biological and medical sciences
Bronchitis - drug therapy
Bronchitis - microbiology
Bronchitis - physiopathology
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Heart Transplantation
Heart-Lung Transplantation
Humans
Lung Transplantation
Male
Postoperative Complications - drug therapy
Prednisone - therapeutic use
Proteins
Respiratory Function Tests
Infection
Heart
Human
Corticosteroid
Chemotherapy
Respiratory disease
Lung
Viral disease
Prednisone
Transplantation
Immunosuppressive agent
Bronchiolitis
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Summary:This report describes the clinical course of a patient who developed obliterative bronchiolitis after viral infection on three separate occasions. Long-term follow-up is given. It is suggested that the syndrome of late pulmonary deterioration after transplantation may be steroid responsive if treatment is initiated early in the natural history of the syndrome. In addition, it is suggested that increased emphasis should be placed on the documentation of viral infection in transplant recipients to define a possible interaction between infection and rejection.
Bibliography:ObjectType-Case Study-3
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-2
ISSN:0022-5223
1097-685X
DOI:10.1016/s0022-5223(19)35800-3