Transforming the Promise of Pluripotent Stem Cell-Derived Cardiomyocytes to a Therapy: Challenges and Solutions for Clinical Trials

• Published in: Canadian journal of cardiology Vol. 30; no. 11; pp. 1335 - 1349
• Main Authors: Prowse, Andrew B.J., PhD, Timmins, Nicholas E., PhD, Yau, Terrence M., MD, MSc, FRCSC, Li, Ren-Ke, MD, PhD, Weisel, Richard D., MD, FRCSC, Keller, Gordon, PhD, Zandstra, Peter W., PhD
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.11.2014
• Subjects: Cardiovascular; Clinical Trials as Topic - methods; Heart Diseases - pathology; Heart Diseases - therapy; Humans; Myocytes, Cardiac - cytology; Pluripotent Stem Cells - transplantation; Stem Cell Transplantation - methods
• ISSN: 0828-282X; 1916-7075
• DOI: 10.1016/j.cjca.2014.08.005

Abstract Despite advances in coronary artery disease treatment and prevention, myocardial damage due to acute myocardial infarction (MI) remains a major cause of morbidity and mortality in the population. Cell-based clinical trials to treat MI have focused on cells derived from the bone marrow or those potentially possessing functional similarities such as skeletal myoblasts or cardiac progenitors isolated from heart biopsies. Any benefits provided by these cells in improving heart function, left ventricular ejection fraction, or extending life expectancy after MI have been credited mostly to paracrine effects. Functional restoration of damaged myocardium will require a functional cell type with similar phenotype and characteristics of the damaged tissue that can also integrate, survive, and electrically couple to the host. Human pluripotent stem cells (hPSCs) have the ability to differentiate into multiple cell types of the adult body. hPSC-derived cardiomyocytes represent a promising target population for cell-based therapies for MI because they are scalable and the product can be defined with a specific set of release criteria. The purpose of this article is to review the rationale for cell therapy in heart disease, discuss the properties of hPSC cardiomyocytes that define their usefulness for regenerative therapy, consider manufacturing issues and preclinical investigation, and finally examine the steps required to establish effective clinical implementation. Pluripotent stem cell-derived cardiomyocyte-based therapies have enormous potential to revolutionize the management of heart disease; expedient but careful development is needed to ensure that this potential is fully realized.