Cell cycle dynamics and complement expression distinguishes mature haematopoietic subsets arising from hemogenic endothelium
The emergence of haematopoietic stem and progenitor cells (HSPCs) from hemogenic endothelium results in the formation of sizeable HSPC clusters attached to the vascular wall. We evaluate the cell cycle and proliferation of HSPCs involved in cluster formation, as well as the molecular signatures from...
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Published in | Cell cycle (Georgetown, Tex.) Vol. 16; no. 19; pp. 1835 - 1847 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Taylor & Francis
02.10.2017
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Subjects | |
Online Access | Get full text |
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Summary: | The emergence of haematopoietic stem and progenitor cells (HSPCs) from hemogenic endothelium results in the formation of sizeable HSPC clusters attached to the vascular wall. We evaluate the cell cycle and proliferation of HSPCs involved in cluster formation, as well as the molecular signatures from their initial appearance to the point when cluster cells are capable of adult engraftment (definitive HSCs). We uncover a non-clonal origin of HSPC clusters with differing cell cycle, migration, and cell signaling attributes. In addition, we find that the complement cascade is highly enriched in mature HSPC clusters, possibly delineating a new role for this pathway in engraftment. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Supplemental data for this article can be accessed on the publisher's website. |
ISSN: | 1538-4101 1551-4005 |
DOI: | 10.1080/15384101.2017.1361569 |