On- and off-exercise kinetics of cardiac output in response to cycling and walking in COPD patients with GOLD Stages I–IV

• Published in: Respiratory physiology & neurobiology Vol. 181; no. 3; pp. 351 - 358
• Main Authors: Vasilopoulou, M.K, Vogiatzis, I, Nasis, I, Spetsioti, S, Cherouveim, E, Koskolou, M, Kortianou, E.A, Louvaris, Z, Kaltsakas, G, Koutsoukou, A, Koulouris, N.G, Alchanatis, M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 31.05.2012
• Subjects: Adaptation, Physiological; Aged; Bicycling; Cardiac output; Cardiac Output - physiology; Case-Control Studies; COPD; Exercise - physiology; Female; Heart Rate - physiology; Hemodynamic kinetic responses; Hemodynamics; Humans; Male; Matched-Pair Analysis; Medical Education; Middle Aged; Pulmonary Disease, Chronic Obstructive - classification; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary/Respiratory; Reference Values; Respiratory Mechanics; Severity of Illness Index; Stroke Volume - physiology; Walking; Hemodynamic kinetic responses; Cardiac output; COPD
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2012.03.014

Highlights ► Abnormalities in respiratory system mechanics induce negative cardiovascular effects during exercise in patients with COPD. ► It is anticipated that the greater the severity of COPD the greater would be the impairment in central hemodynamic responses to exercise. ► Assessment of cardiac output can be performed non-invasively in patients with COPD across all GOLD Stages during exercise. ► Mean response time of cardiac output in the transition from rest to constant-load exercise is delayed in patients with severe as compared to moderate COPD, thus indicating that disease progression worsens the hemodynamic response to exercise.