Dysbiosis—A consequence of Paneth cell dysfunction

Highlights • Paneth cells appear at a critical GI mucosal interface between host and environment. • Paneth cells secrete diverse antimicrobial peptides, shaping microbiota composition. • Paneth cell function can be disrupted by numerous genetic and environmental factors. • Dysfunction of Paneth cell...

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Bibliographic Details
Published inSeminars in immunology Vol. 25; no. 5; pp. 334 - 341
Main Authors Salzman, Nita H, Bevins, Charles L
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 30.11.2013
Subjects
Allergy and Immunology
Animals
Antimicrobial peptides
Defensins
Dysbiosis
Dysbiosis - microbiology
Dysbiosis - pathology
Humans
Microbiota
Paneth cell
Paneth Cells - microbiology
Paneth Cells - pathology
Paneth Cells - physiology
Paneth cell
Microbiota
Defensins
Dysbiosis
Antimicrobial peptides
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Summary:Highlights • Paneth cells appear at a critical GI mucosal interface between host and environment. • Paneth cells secrete diverse antimicrobial peptides, shaping microbiota composition. • Paneth cell function can be disrupted by numerous genetic and environmental factors. • Dysfunction of Paneth cells compromises antimicrobial secretion leading to dysbiosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2013.09.006