Double intratibial injection of human tonsil-derived mesenchymal stromal cells recovers postmenopausal osteoporotic bone mass

• Published in: Cytotherapy (Oxford, England) Vol. 20; no. 8; pp. 1013 - 1027
• Main Authors: KIM, GYUNGAH, JIN, YOON MI, YU, YEONSIL, KIM, HA YEONG, JO, SANGMEE AHN, PARK, YOON JEONG, PARK, YOON SHIN, JO, INHO
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.08.2018
• Subjects: Advanced Basic Science; Animals; Bone Density - physiology; Child; Female; femoral head; Heterografts; Humans; Infusions, Intraosseous - methods; Injections; intratibial injection; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stem Cells - cytology; Mice; Mice, Inbred ICR; Middle Aged; osteoporosis; Osteoporosis - diagnosis; Osteoporosis - pathology; Osteoporosis - therapy; Other; ovariectomized; Palatine Tonsil - cytology; Postmenopause - physiology; Remission Induction; Tibia - diagnostic imaging; tonsil-derived mesenchymal stem cells; visceral fat; femoral head; intratibial injection; ovariectomized; osteoporosis; tonsil-derived mesenchymal stem cells; visceral fat

Abstract Background and aims Osteoporosis, which is a disease characterized by weakening of the bone, affects a large portion of the senior population. The current therapeutic options for osteoporosis have side effects, and there is no effective treatment for severe osteoporosis. Thus, we urgently n...