Implication of Tumor Location for Lymph Node Metastasis in Maxillary Sinus Carcinoma: Indications for Elective Neck Treatment

• Published in: Journal of oral and maxillofacial surgery Vol. 75; no. 4; pp. 858 - 866
• Main Authors: Jeon, Seung Hyuck, MD, Han, Doo Hee, MD, PhD, Won, Tae-Bin, MD, PhD, Keam, Bhumsuk, MD, PhD, Kim, Ji-Hoon, MD, PhD, Wu, Hong-Gyun, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2017
• Subjects: Carcinoma, Squamous Cell - diagnostic imaging; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Dentistry; Diagnostic Imaging; Female; Humans; Lymphatic Metastasis - diagnostic imaging; Lymphatic Metastasis - pathology; Male; Maxillary Neoplasms - diagnostic imaging; Maxillary Neoplasms - pathology; Maxillary Neoplasms - surgery; Middle Aged; Neoplasm Staging; Retrospective Studies; Risk Factors; Surgery; Survival Rate
• ISSN: 0278-2391; 1531-5053
• DOI: 10.1016/j.joms.2016.10.004

Purpose For either neck irradiation or dissection, the indications for elective neck treatment (ENT) of maxillary sinus carcinoma are still unclear. The purpose of the present study was to investigate the relationship between the anatomic extent of the disease and lymph node metastasis in maxillary sinus carcinoma and to propose a recommendation regarding ENT. Materials and Methods In the present retrospective cohort study, patients with squamous cell carcinoma (SCC) and undifferentiated carcinoma (UDC) of maxillary sinus treated with radical intent from January 1995 to June 2015 in a single institution were recruited by retrospective medical record review. The demographic and tumor characteristics of the patients and maxillary sinus wall invasion, verified on pretreatment volumetric imaging studies, were analyzed. The Cox proportional hazards model was used to find the risk factors for nodal relapse, distant metastasis, and survival. Results Among a total of 71 identified patients, 66 had SCC and 5 had UDC. In 55 patients with node-negative disease, the risk of ipsilateral nodal relapse was 25.1% without ENT. In contrast, no ipsilateral nodal relapse was reported after ENT. On multivariate analysis, no chemotherapy (hazard ratio [HR] = 7.25; P  = .01), posterior wall invasion (HR = 6.51; P  = .03), and local failure (HR = 6.42; P  = .02) were identified to be the risk factors of nodal relapse. Nodal relapse influenced the risk of distant metastasis with marginal significance (HR = 3.95; P  = .07) but did not have an effect on survival. The most common regions of lymph node metastasis, at both initial presentation and relapse, were ipsilateral levels I and II. Conclusions For SCC and UDC of the maxillary sinus with posterior wall invasion, ENT involving ipsilateral levels I and II is recommended. Future studies with larger numbers of patients are needed to validate our conclusion.