Elderly ovarian cancer patients: An individual participant data meta-analysis of the North-Eastern German Society of Gynecological Oncology (NOGGO)

• Published in: European journal of cancer (1990) Vol. 60; pp. 101 - 106
• Main Authors: Woopen, H, Inci, G, Richter, R, Chekerov, R, Ismaeel, F, Sehouli, J
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2016
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cardiovascular Diseases - chemically induced; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Elderly; Female; Germany - epidemiology; Hematologic Diseases - chemically induced; Hematology, Oncology and Palliative Medicine; Humans; Kaplan-Meier Estimate; Middle Aged; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - mortality; Recurrent ovarian cancer; Toxicity; Treatment Outcome; Young Adult; Toxicity; Elderly; Recurrent ovarian cancer
• ISSN: 0959-8049; 1879-0852
• DOI: 10.1016/j.ejca.2016.03.008

Abstract Background Barriers for optimal treatment and enrolment in clinical trials are the physicians' perceptions towards age, comorbidities and fear of toxicity as well as the eligibility criteria of clinical trials. There is a high need to gain more knowledge about this patient group in order to optimize treatment. We aimed to evaluate the influence of age above 65 years on comorbidities, comedication, grade III/IV toxicity, prior discontinuation of chemotherapy and survival. Patients and methods An individual participant data meta-analysis of three phase II/III studies (‘Tower’, ‘Topotecan phase III’ and ‘Hector’) of the North-Eastern German Society of Gynecological Oncology including 1213 patients with recurrent ovarian cancer was conducted using logistic regression and Cox regression analysis. Results Median age at diagnosis was 59 years. The patient group ≥65 years included 349 versus 864 patients younger than 65 years. Cardiovascular disease and diabetes were more frequent in the older age group (p < 0.001 and p = 0.001). Haematological and cardiovascular grade III/IV toxicities were more often seen in patients above 65 years, while non-haematological toxicity was not (p = 0.03, odds ratio [OR] 1.35; p = 0.04, OR 1.83; and p = 0.90, OR 0.98, respectively). There was no difference in prior discontinuation of treatment in multivariate analysis. Cox regression showed a trend towards poorer progression-free survival (p = 0.053, hazard ratio 1.143) in the older age group. Conclusion Haematological and cardiovascular toxicities are more frequent in elderly patients. However, this did not influence prior discontinuation of therapy. Elderly patients should not be deprived of adequate chemotherapy or excluded from clinical studies just because of their age. Thorough geriatric assessment and monitoring is mandatory.