The role of microRNAs in tumors

The cancers are a series of serious diseases in the world, and the mechanism involved in many cancers has not yet been fully elucidated. Therefore, it is a very major and significant to explore the molecular mechanisms of cancer occurence and development. MicroRNAs (miRNAs), a class of molecules tha...

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Published inArchives of pharmacal research Vol. 36; no. 10; pp. 1169 - 1177
Main Author Liu, Chuanxin
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.10.2013
대한약학회
Subjects
biomarkers
carcinogenesis
Carcinogenesis - genetics
Gene Expression Regulation, Neoplastic - genetics
genes
Humans
Medicine
microRNA
MicroRNAs - genetics
neoplasms
Pharmacology/Toxicology
Pharmacy
Review
약학
Tumorigenesis
MicroRNAs
Leukemia
Cancer
Apoptosis
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Abstract The cancers are a series of serious diseases in the world, and the mechanism involved in many cancers has not yet been fully elucidated. Therefore, it is a very major and significant to explore the molecular mechanisms of cancer occurence and development. MicroRNAs (miRNAs), a class of molecules that regulates gene at post-transcription expression, play an important role in tumorigenesis. It has been proved that a number of miRNAs identified as aberrantly expressed during cancer development. In addition, some of the miRNAs may have prognostic significance. It is the aim of this review to describe the important role of miRNAs in cancer initiation and development as predictive, diagnostic, prognostic biomarkers and novel therapeutic strategies.
AbstractList The cancers are a series of serious diseases in the world, and the mechanism involved in many cancers has not yet been fully elucidated. Therefore, it is a very major and significant to explore the molecular mechanisms of cancer occurence and development. MicroRNAs (miRNAs), a class of molecules that regulates gene at post-transcription expression, play an important role in tumorigenesis. It has been proved that a number of miRNAs identified as aberrantly expressed during cancer development. In addition, some of the miRNAs may have prognostic significance. It is the aim of this review to describe the important role of miRNAs in cancer initiation and development as predictive, diagnostic, prognostic biomarkers and novel therapeutic strategies.
The cancers are a series of serious diseases in the world, and the mechanism involved in many cancers has not yet been fully elucidated. Therefore, it is a very major and significant to explore the molecular mechanisms of cancer occurence and development. MicroRNAs (miRNAs), a class of molecules that regulates gene at post-transcription expression, play an important role in tumorigenesis. It has been proved that a number of miRNAs identified as aberrantly expressed during cancer development. In addition, some of the miRNAs may have prognostic significance. It is the aim of this review to describe the important role of miRNAs in cancer initiation and development as predictive, diagnostic, prognostic biomarkers and novel therapeutic strategies.The cancers are a series of serious diseases in the world, and the mechanism involved in many cancers has not yet been fully elucidated. Therefore, it is a very major and significant to explore the molecular mechanisms of cancer occurence and development. MicroRNAs (miRNAs), a class of molecules that regulates gene at post-transcription expression, play an important role in tumorigenesis. It has been proved that a number of miRNAs identified as aberrantly expressed during cancer development. In addition, some of the miRNAs may have prognostic significance. It is the aim of this review to describe the important role of miRNAs in cancer initiation and development as predictive, diagnostic, prognostic biomarkers and novel therapeutic strategies.
The cancers are a series of serious diseases inthe world, and the mechanism involved in many cancershas not yet been fully elucidated. Therefore, it is a verymajor and significant to explore the molecular mechanismsof cancer occurence and development. MicroRNAs (miRNAs),a class of molecules that regulates gene at posttranscriptionexpression, play an important role in tumorigenesis. It has been proved that a number of miRNAsidentified as aberrantly expressed during cancer development. In addition, some of the miRNAs may have prognosticsignificance. It is the aim of this review to describethe important role of miRNAs in cancer initiation anddevelopment as predictive, diagnostic, prognostic biomarkersand novel therapeutic strategies. KCI Citation Count: 6
Author Liu, Chuanxin
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CitedBy_id crossref_primary_10_1042_BSR20180078
crossref_primary_10_1093_carcin_bgw078
crossref_primary_10_1016_j_mam_2019_03_002
crossref_primary_10_5306_wjco_v5_i3_323
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Snippet The cancers are a series of serious diseases in the world, and the mechanism involved in many cancers has not yet been fully elucidated. Therefore, it is a...
The cancers are a series of serious diseases inthe world, and the mechanism involved in many cancershas not yet been fully elucidated. Therefore, it is a...
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SubjectTerms biomarkers
carcinogenesis
Carcinogenesis - genetics
Gene Expression Regulation, Neoplastic - genetics
genes
Humans
Medicine
microRNA
MicroRNAs - genetics
neoplasms
Pharmacology/Toxicology
Pharmacy
Review
약학
Title The role of microRNAs in tumors
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